ArticleJournal of molecular histology2017
Histological evidence that metformin reverses the adverse effects of diabetes on orthodontic tooth movement in rats.
Article in Journal of molecular histology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Effects of anti-diabetic medications on the teeth, oral soft and hard tissues, saliva, and implants: a scoping review.BDJ open · 2026Review
- Chronic intermittent hypoxia impairs BM-MSC osteogenesis and long bone growth through regulating histone lactylation.Journal of translational medicine · 2025Article
- The Influence of Diabetes on Orthodontic Treatment: A Systematic Review of the Clinical Considerations and Challenges in Response.Journal of clinical medicine · 2025Review
- Metformin and bone metabolism: unraveling their direct and indirect effects.Therapeutic advances in endocrinology and metabolism · 2025Review
- Optimized Nanostructured Lipid Carriers for Metformin: Enhanced Anti-Inflammatory Activity and Protection Against Type 2 Diabetes-Induced Organ Damage.International journal of nanomedicine · 2025Article
- Applications of Metformin in Dentistry-A review.Journal of Taibah University Medical Sciences · 2023Review
- Effects of Metformin on Bone Mineral Density and Adiposity-Associated Pathways in Animal Models with Type 2 Diabetes Mellitus: A Systematic Review.Journal of clinical medicine · 2022Review
- Effects of diabetes on oxidative stress, periodontal ligament fiber orientation, and matrix metalloproteinase 8 and 9 expressions during orthodontic tooth movement.Clinical oral investigations · 2021Article
- Diabetes Medication Metformin Inhibits Osteoclast Formation and Activity inFrontiers in cell and developmental biology · 2021Article
- Mechanical stress alters protein O-GlcNAc in human periodontal ligament cells.Journal of cellular and molecular medicine · 2019Article
- Periodontal ligament-associated protein-1 gets involved in the development of osseous eruption canal.Journal of molecular histology · 2019Article
- Diabetes pharmacotherapy and effects on the musculoskeletal system.Diabetes/metabolism research and reviews · 2019Review
- Role of Metformin on Osteoblast Differentiation in Type 2 Diabetes.BioMed research international · 2019Review
- Favorable outcomes of metformin on coronary microvasculature in experimental diabetic cardiomyopathy.Journal of molecular histology · 2018Article
- Transcriptional activation of glucose transporter 1 in orthodontic tooth movement-associated mechanical response.International journal of oral science · 2018Article
- Osteoprotegerin deficiency causes morphological and quantitative damage in epithelial rests of Malassez.Journal of molecular histology · 2018Article
- Tension force-induced bone formation in orthodontic tooth movement via modulation of the GSK-3β/β-catenin signaling pathway.Journal of molecular histology · 2018Article
- CTHRC1 promotes osteogenic differentiation of periodontal ligament stem cells by regulating TAZ.Journal of molecular histology · 2017Article
- Effect of corticision on orthodontic tooth movement in a rat model as assessed by RNA sequencing.Journal of molecular histology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study evaluated the effects of metformin on orthodontic tooth movement in a rat model of type 2 diabetes mellitus. Rats were fed a high-fat diet for 4 weeks to induce fat accumulation and insulin resistance, and then injected with a low dose of streptozotocin (35 mg/kg) intraperitoneally to induce type 2 diabetes. An orthodontic appliance was placed in normoglycemic, type 2 diabetes, and type 2 diabetes with metformin-administrated rats. After 14 days, type 2 diabetes rats exhibited greater orthodontic tooth movement and had a higher number of tartrate-resistant acid phosphatase-positive osteoclasts, stronger cathepsin K expression, and weaker alkaline phosphatase immunostaining than normoglycemic rats. Metformin administration resulted in normalization of osteoclast numbers, cathepsin K immunostaining, and of tooth movement as well as partly recovery of alkaline phosphatase expression in diabetic rats. Metformin also reduced sclerostin expression and improved the immunolocalization of dentin matrix protein 1 in osteocytes of type 2 diabetes rats. These results suggest that metformin administration reversed the adverse effects of diabetes on orthodontic tooth movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.