ReviewJournal of neurology2017
The clinical heterogeneity of drug-induced myoclonus: an illustrated review.
Review in Journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Drug-Induced Myoclonus: A Systematic Review.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Sex-specific pharmacovigilance signals and time-to-onset patterns of drug-related myoclonus and epileptic seizures: a real-world pharmacovigilance analysis.Frontiers in pharmacology · 2026Article
- A Case Report of Encephalopathy With Myoclonus: A Rare Neurologic Side Effect of Ranolazine.Cureus · 2025Article
- Clozapine-Induced Negative Myoclonus Leads to Recurrent Falls: A Case Report.Journal of movement disorders · 2025Article
- Recognizing pediatric febrile myoclonus: a video-documented case report and review of the current literature.Frontiers in pediatrics · 2025Article
- Article
- Amisulpride-induced myoclonus: A unique tardive syndrome.Indian journal of psychiatry · 2024Article
- Myoclonus: Differential diagnosis and current management.Epilepsia open · 2024Review
- Dobutamine-Induced Myoclonus in a Patient With Advanced Heart Failure and Chronic Kidney Disease.JACC. Case reports · 2024Article
- Amantadine-Induced Craniofacial Myoclonus: Distinctive Iatrogenic Dysarthria in Parkinson's Disease.Movement disorders clinical practice · 2023Review
- Myoclonus Secondary to Amantadine: Case Report and Literature Review.Clinics and practice · 2023Article
- Levetiracetam-induced myoclonus following recovery from non-convulsive status epilepticus in an elderly woman.Internal and emergency medicine · 2022Article
- Treatable Hyperkinetic Movement Disorders Not to Be Missed.Frontiers in neurology · 2021Review
- Assessment of Extrapyramidal Symptoms Associated with Psychotropics Pharmacological Treatments, and Associated Risk Factors.Clinical practice and epidemiology in mental health : CP & EMH · 2021Article
- Myoclonus induced by amoxicillin-clavulanic acid.Epilepsy & behavior reports · 2020Article
- Myoclonic Disorders.Brain sciences · 2017Review
- Presumed gabapentin-induced myoclonus in two cats.JFMS open reportsArticle
- Acamprosate-induced myoclonic jerks: A rare side effect.Indian journal of pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A wide variety of drugs can cause myoclonus. To illustrate this, we first discuss two personally observed cases, one presenting with generalized, but facial-predominant, myoclonus that was induced by amantadine; and the other presenting with propriospinal myoclonus triggered by an antibiotic. We then review the literature on drugs that may cause myoclonus, extracting the corresponding clinical phenotype and suggested underlying pathophysiology. The most frequently reported classes of drugs causing myoclonus include opiates, antidepressants, antipsychotics, and antibiotics. The distribution of myoclonus ranges from focal to generalized, even amongst patients using the same drug, which suggests various neuro-anatomical generators. Possible underlying pathophysiological alterations involve serotonin, dopamine, GABA, and glutamate-related processes at various levels of the neuraxis. The high number of cases of drug-induced myoclonus, together with their reported heterogeneous clinical characteristics, underscores the importance of considering drugs as a possible cause of myoclonus, regardless of its clinical characteristics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.