Evidence map›Paper›PMID 27981253›Full record

ArticleInternational journal of reproductive biomedicine2016

Efficacy of Intrauterine infusion of granulocyte colony stimulating factor on patients with history of implantation failure: A randomized control trial.

Maryam Eftekhar, Sepideh Miraj, Maryam Farid Mojtahedi, Nosrat Neghab

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of reproductive biomedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 21 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 8 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04998279 completednot on this mapstarted 2019, after this paper: background citation

Intrauterine Infusion of Granulocyte Colony Stimulating Factor and Reproductive Outcomes in Infertile Women with History of Recurrent Implantation Failure

TypeobservationalSponsorCairo UniversityRan2019 to 2024Enrolled100ConditionsRecurrent Implantation Failure, Granulocyte Colony-Stimulating Factor, InfertilityArmsGranulocyte Colony-Stimulating Factor, placebo
NCT06174298 phase4unknown statusnot on this mapstarted 2024, after this paper: background citation

The Role of Granulocyte Colony Stimulating Factor in Embryo Transfer Outcomes

TypeinterventionalSponsorNewlife Fertility CentreRan2024 to 2025Enrolled300ConditionsInfertility, Infertility,Female, Infertility, Female, NonimplantationArmsGranulocyte Colony-Stimulating Factor (Filgrastim), Standard Embryo Transfer Media
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 8 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  9. Review
  10. Platelet-rich plasma versus granulocyte colony-stimulating factor in addressing recurrent implantation failure: A randomized, double-blind clinical trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2026
    Article
  11. Observational
  12. Review
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  20. Role of granulocyte colony-stimulating factor in human reproduction.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Maryam EftekharResearch and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Sepideh MirajResearch and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.; Department of Obstetrics and Gynecology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Maryam Farid MojtahediDepartment of Obstetrics and Gynecology, Endocrinology and Female Infertility Unit, Roointan Arash Women's Health Research and Educational Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Nosrat NeghabResearch and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Shahid Sadoughi University of Medical Sciences and Health Services · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough pregnancy rate in in vitro fertilization-embryo transfer (IVF-ET) cycles has been increased over the preceding years, but the majority of IVF-ET cycles still fail. Granulocyte colony stimulating factor (GCSF) is a glycoprotein that stimulates cytokine growth factor and induces immune system which may improve pregnancy rate in women with history of implantation failure.

objectiveThe aim of this study was to evaluate GCSF ability to improve pregnancy rate in women with history of implantation failure. MATERIALS AND

methods0.5 ml (300 µg/ml) GCSF was infused intrauterine in intervention group. Pregnancy outcomes were assessed based on clinical pregnancy.

resultsThe mean age of participants was 31.95±4.71 years old. There were no significant differences between demographic characteristics in two groups (p>0.05). The pregnancy outcome in GCSF group was improved significantly (p=0.043).

conclusionGCSF can improve pregnancy outcome in patients with history of implantation failure.

Indexed as

GCSFIn vitro fertilizationPregnancy rate

Identifiers

PMID27981253
PMCPMC5153573
OpenAlexW2554307943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.