Evidence map›Paper›PMID 27981188›Full record

ArticleNeurobiology of stress2016

Maternal immune activation epigenetically regulates hippocampal serotonin transporter levels.

Sonali N Reisinger, Eryan Kong, Deeba Khan, Stefan Schulz, Marianne Ronovsky, Stefanie Berger, Orsolya Horvath, Maureen Cabatic, Angelika Berger, Daniela D Pollak

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of stress, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sonali N ReisingerDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Austria.
Eryan KongDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Austria.
Deeba KhanDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Austria.
Stefan SchulzDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Austria.
Marianne RonovskyDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Austria.
Stefanie BergerDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Austria.
Orsolya HorvathDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Austria.
Maureen CabaticDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Austria.
Angelika BergerDepartment of Pediatrics and Adolescent Medicine, Medical University of Vienna, Austria.
Daniela D PollakDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Austria.
Institute for Pharmaeconomic Research · ATMedical University of Vienna · AT

Funding

Austrian Science Fund FWF P 27520
6 · The paper itself

Abstract

Major depressive disorder (MDD) is one of the most debilitating psychiatric diseases, affecting a large percentage of the population worldwide. Currently, the underlying pathomechanisms remain incompletely understood, hampering the development of critically needed alternative therapeutic strategies, which further largely depends on the availability of suitable model systems. Here we used a mouse model of early life stress - a precipitating factor for the development of MDD - featuring infectious stress through maternal immune activation (MIA) by polyinosinic:polycytidilic acid (Poly(I:C)) to examine epigenetic modulations as potential molecular correlates of the alterations in brain structure, function and behavior. We found that in adult female MIA offspring anhedonic behavior was associated with modulations of the global histone acetylation profile in the hippocampus. Morevoer, specific changes at the promoter and in the expression of the serotonin transporter (SERT), critically involved in the etiology of MDD and pharmacological antidepressant treatment were detected. Furthermore, an accompanying reduction in hippocampal levels of histone deacetylase (HDAC) 1 was observed in MIA as compared to control offspring. Based on these results we propose a model in which the long-lasting impact of MIA on depression-like behavior and associated molecular and cellular aberrations in the offspring is brought about by the modulation of epigenetic processes and consequent enduring changes in gene expression. These data provide additional insights into the principles underlying the impact of early infectious stress on the development of MDD and may contribute to the development of new targets for antidepressant therapy.

Indexed as

DepressionEpigeneticsHistone acetylationInfectious stressMaternal immune activationSerotonin transporter

Identifiers

PMID27981188
PMCPMC5146201
OpenAlexW2283818958

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.