ArticleNeurobiology of stress2016
Sex differences in sleep, anhedonia, and HPA axis activity in a rat model of chronic social defeat.
Article in Neurobiology of stress, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Central amygdalaNeurobiology of stress · 2026Article
- New Insights into Contradictory Changes in Brain-Derived Neurotrophic Factor (BDNF) in Rodent Models of Posttraumatic Stress Disorder (PTSD).Neurochemical research · 2024Review
- Sex differences in body temperature and neural power spectra in response to repeated restraint stress.Stress (Amsterdam, Netherlands) · 2024Article
- Individual differences in social homeostasis.Frontiers in behavioral neuroscience · 2023Review
- A noradrenergic-hypothalamic neural substrate for stress-induced sleep disturbances.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Sex Differences in Depression-Like Behaviors in Adult Mice Depend on Endophenotype and Strain.Frontiers in behavioral neuroscience · 2022Article
- Sex differences in behavioral, cognitive and voluntary ethanol-intake effects in Dexamethasone-induced depression-like state in Wistar rat.AIMS neuroscience · 2022Article
- Chronic antidepressant treatment rescues abnormally reduced REM sleep theta power in socially defeated rats.Scientific reports · 2021Article
- Sex-Dependent Effects of Chronic Social Defeat on Emotional and Social Behaviors, and Parameters of Oxytocin and Vasopressin Systems in Mandarin Voles (Frontiers in neuroscience · 2021Article
- Anhedonic Type Behavior and Anxiety Profile of Wistar-UIS Rats Subjected to Chronic Social Isolation.Frontiers in behavioral neuroscience · 2021Article
- Article
- The influence of stress and early life adversity on addiction: Psychobiological mechanisms of risk and resilience.International review of neurobiology · 2020Review
- The future of rodent models in depression research.Nature reviews. Neuroscience · 2019Review
- Abnormalities in Inflammatory Cytokines Confer Susceptible to Chronic Neuropathic Pain-related Anhedonia in a Rat Model of Spared Nerve Injury.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2019Article
- REM sleep's unique associations with corticosterone regulation, apoptotic pathways, and behavior in chronic stress in mice.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Association of T and non-T cell cytokines with anhedonia: Role of gender differences.Psychoneuroendocrinology · 2018Article
- Current Status of Animal Models of Posttraumatic Stress Disorder: Behavioral and Biological Phenotypes, and Future Challenges in Improving Translation.Biological psychiatry · 2018Review
- Rat Strain and Housing Conditions Alter Oxidative Stress and Hormone Responses to Chronic Intermittent Hypoxia.Frontiers in physiology · 2018Article
- Effects of Chronic Social Defeat Stress on Sleep and Circadian Rhythms Are Mitigated by Kappa-Opioid Receptor Antagonism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Repeated bouts of a major stressor such as social defeat are well known to induce a depression phenotype in male rats. Despite strong evidence and acknowledgement that women have a two-fold lifetime greater risk of developing major depression compared to men, the inclusion of female rats in studies employing social defeat are very rare; their absence is attributed to less aggressive interactions. This study sought to compare in male and female rats the impact of repeated social defeat, three times per week for four weeks, on the development of changes in sleep architecture and continuity, sucrose preference as a measure of anhedonia, changes in body weight, and basal plasma corticosterone levels. We found significant reductions in rapid eye movement sleep (REMS) during the light phase in both females and males, and significant increases in numbers of vigilance state transitions during the early dark phase in females but not in males. Additionally, females exhibited significantly greater reductions in sucrose intake than males. On the other hand, no sex differences in significantly elevated basal corticosterone levels were evident, and only the males exhibited changes in body weight. Taken together these findings suggest that the inclusion of female rats in studies of social defeat may offer greater insights in studies of stress and depression.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.