ArticleNeuroImage. Clinical2017
Probabilistic mapping of deep brain stimulation effects in essential tremor.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 118 citations in OpenAlex.
- Mapping autonomic, mood and cognitive effects of hypothalamic region deep brain stimulation.Brain : a journal of neurology · 2021Trial
- Probabilistic mapping of tremor control and gait ataxia risk in deep brain stimulation.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Deconstructing a common pathway concept for Deep Brain Stimulation in the case of Obsessive-Compulsive Disorder.Molecular psychiatry · 2025Article
- Convergent mapping of a tremor treatment network.Nature communications · 2025Article
- Potential of Individual Upper-Limb Muscles to Contribute to Postural Tremor: Simulations From Neural Drive to Joint Rotation.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Towards robust probabilistic maps in Deep Brain Stimulation: exploring the impact of patient number, stimulation counts, and statistical approaches.Frontiers in computational neuroscience · 2025Article
- Functional anatomy of the subthalamic nucleus and the pathophysiology of cardinal features of Parkinson's disease unraveled by focused ultrasound ablation.Science advances · 2024Article
- The role of the motor thalamus in deep brain stimulation for essential tremor.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- Amelioration of Parkinsonian tremor evoked by DBS: which role play cerebello-(sub)thalamic fiber tracts?Journal of neurology · 2024Article
- Computational Neurosurgery in Deep Brain Stimulation.Advances in experimental medicine and biology · 2024Review
- Effects of Low-Frequency Deep Brain Stimulation in Bilateral Zona Incerta for a Patient With Tremor and Cerebellar Ataxia.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Modeling the volume of tissue activated in deep brain stimulation and its clinical influence: a review.Frontiers in human neuroscience · 2024Review
- Exploring the network effects of deep brain stimulation for rapid eye movement sleep behavior disorder in Parkinson's disease.Acta neurochirurgica · 2023Article
- Article
- How Sample Size Impacts Probabilistic Stimulation Maps in Deep Brain Stimulation.Brain sciences · 2023Article
- Anatomical substrates and connectivity for bradykinesia motor features in Parkinson's disease after subthalamic nucleus deep brain stimulation.Brain communications · 2023Article
- Multiple input algorithm-guided Deep Brain stimulation-programming for Parkinson's disease patients.NPJ Parkinson's disease · 2022Article
- Article
- Deep Brain Stimulation: Emerging Tools for Simulation, Data Analysis, and Visualization.Frontiers in neuroscience · 2022Review
- Distribution of electric field in patients with obsessive compulsive disorder treated with deep brain stimulation of the bed nucleus of stria terminalis.Acta neurochirurgica · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo create probabilistic stimulation maps (PSMs) of deep brain stimulation (DBS) effects on tremor suppression and stimulation-induced side-effects in patients with essential tremor (ET).
methodMonopolar reviews from 16 ET-patients which consisted of over 600 stimulation settings were used to create PSMs. A spherical model of the volume of neural activation was used to estimate the spatial extent of DBS for each setting. All data was pooled and voxel-wise statistical analysis as well as nonparametric permutation testing was used to confirm the validity of the PSMs.
resultsPSMs showed tremor suppression to be more pronounced by stimulation in the zona incerta (ZI) than in the ventral intermediate nucleus (VIM). Paresthesias and dizziness were most commonly associated with stimulation in the ZI and surrounding thalamic nuclei. DISCUSSION: Our results support the assumption, that the ZI might be a very effective target for tremor suppression. However stimulation inside the ZI and in its close vicinity was also related to the occurrence of stimulation-induced side-effects, so it remains unclear whether the VIM or the ZI is the overall better target. The study demonstrates the use of PSMs for target selection and evaluation. While their accuracy has to be carefully discussed, they can improve the understanding of DBS effects and can be of use for other DBS targets in the therapy of neurological or psychiatric disorders as well. Furthermore they provide a priori information about expected DBS effects in a certain region and might be helpful to clinicians in programming DBS devices in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.