ReviewBasic and clinical andrology2016
Sperm DNA damage and its role in IVF and ICSI.
Review in Basic and clinical andrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Research progress on the role and mechanism of DNA damage repair in germ cell development.Frontiers in endocrinology · 2023Pooled it
- Coffee and caffeine intake and male infertility: a systematic review.Nutrition journal · 2017Pooled it
- TdT/Cas12a-based biosensor for sensitive detection of DNA breakpoints in sperm cryopreservation.Scientific reports · 2025Article
- Low levels of mouse sperm chromatin fragmentation delay embryo development.Biology of reproduction · 2023Article
- Sperm selection with hyaluronic acid improved live birth outcomes among older couples and was connected to sperm DNA quality, potentially affecting all treatment outcomes.Human reproduction (Oxford, England) · 2022Article
- Technical Evaluation of Commercial Sperm DFI Quality Control Products in SCSA Testing.Journal of healthcare engineering · 2022Article
- ISAR Consensus Guidelines on Add-Ons Treatment inJournal of human reproductive sciences · 2021Article
- Apoptotic M540 bodies present in human semen interfere with flow cytometry-assisted assessment of sperm DNA fragmentation and oxidation.Basic and clinical andrology · 2021Article
- Sperm selection during ICSI treatments reduces single- but not double-strand DNA break values compared to the semen sample.Journal of assisted reproduction and genetics · 2021Article
- Predictive Significance of Sperm DNA Fragmentation Testing in Early Pregnancy Loss in Infertile Couples Undergoing Intracytoplasmic Sperm Injection.Research and reports in urology · 2021Article
- Relationship between sperm morphology and sperm DNA dispersion.Translational andrology and urology · 2020Article
- Utility and Predictive Value of Human Standard Semen Parameters and Sperm DNA Dispersion for Fertility Potential.International journal of environmental research and public health · 2019Article
- Yoga: Impact on sperm genome and epigenome - clinical consequences.Annals of neurosciences · 2019Article
- Lifestyle and fertility: the influence of stress and quality of life on male fertility.Reproductive biology and endocrinology : RB&E · 2018Review
- The effect of human sperm chromatin maturity on ICSI outcomes.Human cell · 2018Article
- A Strengths-Weaknesses-Opportunities-Threats (SWOT) analysis on the clinical utility of sperm DNA fragmentation testing in specific male infertility scenarios.Translational andrology and urology · 2017Article
- Testing of sperm DNA damage and clinical recommendations.Translational andrology and urology · 2017Article
- Commentary on sperm DNA fragmentation testing clinical guideline.Translational andrology and urology · 2017Article
- Evaluation of sperm chromatin structure and DNA strand breaks is an important part of clinical male fertility assessment.Translational andrology and urology · 2017Article
- Eight tests for sperm DNA fragmentation and their roles in the clinic.Translational andrology and urology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the semen analysis has traditionally been relied upon to differentiate fertile and infertile men, its utility has been questioned in the current era of assisted reproductive technologies. The desire for more sophisticated diagnostic and predictive tools has led to increased use of sperm DNA damage in the management of male infertility. Despite the availability of numerous assays to measure sperm DNA damage, our understanding of the etiology, measurement, and clinical implications of sperm DNA damage remains incomplete. While the current evidence is fraught with heterogeneity that complicates attempts at comparison and meta-analysis, there does appear to be a role for sperm DNA damage in the development and maintenance of pregnancy in the era of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). However, as noted by the American Society for Reproductive Medicine, the routine and widespread use of sperm DNA damage testing is not yet supported. Further studies are needed to standardize the measurement of sperm DNA damage and to clarify the exact role of sperm DNA damage within the myriad of other male and female factors contributing to reproductive outcomes in IVF and ICSI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.