Evidence map›Paper›PMID 27980783›Full record

ArticleImmunity, inflammation and disease2016

Joel R Wilmore, Alexander C Maue, Rosemary Rochford

Open access · goldAbstract read
In one paragraph

Article in Immunity, inflammation and disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. The Plasticity of Newly Formed B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Joel R WilmoreDepartment of Microbiology and Immunology SUNY Upstate Medical University Syracuse New York USA.
Alexander C MaueDepartment of Microbiology and Immunology SUNY Upstate Medical University Syracuse New York USA.
Rosemary RochfordDepartment of Microbiology and ImmunologySUNY Upstate Medical UniversitySyracuseNew YorkUSA; Department of Immunology and MicrobiologyUniversity of ColoradoAuroraColoradoUSA.
SUNY Upstate Medical University · USUniversity of Colorado Denver · US

Funding

Effects of Malaria on EBV Persistence in ChildrenR01CA102667 · NCI · UPSTATE MEDICAL UNIVERSITY · PI ROCHFORD, ROSEMARY · 2005 to 2014
$2.9M
NCI NIH HHS R01 CA102667
6 · The paper itself

Abstract

introductionEndemic Burkitt's lymphoma (eBL) is associated with Epstein-Barr virus and repeated malaria infections. A defining feature of eBL is the translocation of the c-myc oncogene to the control of the immunoglobulin promoter. Activation-induced cytidine deaminase (AID) has been shown to be critical for this translocation. Malaria infection induces AID in germinal center B cells, but whether malaria infection more broadly affects AID activation in extrafollicular B cells is unknown.

methodsWe either stimulated purified B cells from AID-green fluorescence protein (GFP) reporter mice or infected AID-GFP mice with

resultsIn vitro analysis of B cells from these mice revealed that CpG (a Toll-like receptor 9 ligand) was a potent inducer of AID in both mature and immature B cell subsets. Infection of AID-GFP mice with

conclusionsThese data suggest that

Indexed as

AICDA (Activation-Induced Cytidine Deaminase)AnimalsB-LymphocytesB-Lymphocyte SubsetsCytidine DeaminaseGerminal CenterMalariaMaleMiceMice, Inbred C57BLPlasmodium chabaudiAICDA (Activation-Induced Cytidine Deaminase)Cytidine Deaminaseactivation‐induced deaminase (AID)B cellsPlasmodium

Identifiers

PMID27980783
PMCPMC5134720
OpenAlexW2558756457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.