Evidence map›Paper›PMID 27980750›Full record

ArticleClinical case reports2016

All-trans retinoic acid (ATRA) in non-promyelocytic acute myeloid leukemia (AML): results of combination of ATRA with low-dose Ara-C in three elderly patients with

Fabio Forghieri, Sara Bigliardi, Chiara Quadrelli, Monica Morselli, Leonardo Potenza, Ambra Paolini, Elisabetta Colaci, Patrizia Barozzi, Patrizia Zucchini, Giovanni Riva and 10 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Clinical case reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. The synergistic effect of c-Myb hyperactivation and Pu.1 deficiency induces Pelger-Huët anomaly and promotes sAML.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 1 country.

Fabio ForghieriDepartment Medical and Surgical Sciences Section of Hematology Azienda Ospedaliero-Universitaria Policlinico University of Modena and Reggio Emilia Modena Italy.
Sara BigliardiDepartment Medical and Surgical Sciences Section of Hematology Azienda Ospedaliero-Universitaria Policlinico University of Modena and Reggio Emilia Modena Italy.
Chiara QuadrelliDepartment Medical and Surgical Sciences Section of Hematology Azienda Ospedaliero-Universitaria Policlinico University of Modena and Reggio Emilia Modena Italy.
Monica MorselliDepartment Medical and Surgical Sciences Section of Hematology Azienda Ospedaliero-Universitaria Policlinico University of Modena and Reggio Emilia Modena Italy.
Leonardo PotenzaDepartment Medical and Surgical Sciences Section of Hematology Azienda Ospedaliero-Universitaria Policlinico University of Modena and Reggio Emilia Modena Italy.
Ambra PaoliniDepartment Medical and Surgical Sciences Section of Hematology Azienda Ospedaliero-Universitaria Policlinico University of Modena and Reggio Emilia Modena Italy.
Elisabetta ColaciDepartment Medical and Surgical Sciences Section of Hematology Azienda Ospedaliero-Universitaria Policlinico University of Modena and Reggio Emilia Modena Italy.
Patrizia BarozziDepartment Medical and Surgical Sciences Section of Hematology Azienda Ospedaliero-Universitaria Policlinico University of Modena and Reggio Emilia Modena Italy.
Patrizia ZucchiniDepartment Medical and Surgical Sciences Section of Hematology Azienda Ospedaliero-Universitaria Policlinico University of Modena and Reggio Emilia Modena Italy.
Giovanni RivaDepartment Medical and Surgical Sciences Section of Hematology Azienda Ospedaliero-Universitaria Policlinico University of Modena and Reggio Emilia Modena Italy.
Daniela ValleriniDepartment Medical and Surgical Sciences Section of Hematology Azienda Ospedaliero-Universitaria Policlinico University of Modena and Reggio Emilia Modena Italy.
Ivana LagrecaDepartment Medical and Surgical Sciences Section of Hematology Azienda Ospedaliero-Universitaria Policlinico University of Modena and Reggio Emilia Modena Italy.
Roberto MarascaDepartment Medical and Surgical Sciences Section of Hematology Azienda Ospedaliero-Universitaria Policlinico University of Modena and Reggio Emilia Modena Italy.
Franco NarniDepartment Medical and Surgical Sciences Section of Hematology Azienda Ospedaliero-Universitaria Policlinico University of Modena and Reggio Emilia Modena Italy.
Adriano VendittiDepartment of Hematology University Tor Vergata Rome Italy.
Maria Paola MartelliInstitute of Hematology CREO (Centro di Ricerca Emato-Oncologico) Ospedale S. Maria della Misericordia, S. Andrea delle Fratte University of Perugia Perugia Italy.
Brunangelo FaliniInstitute of Hematology CREO (Centro di Ricerca Emato-Oncologico) Ospedale S. Maria della Misericordia, S. Andrea delle Fratte University of Perugia Perugia Italy.
Francesco Lo CocoDepartment of Biomedicine and Prevention University Tor Vergata Rome Italy.
Sergio AmadoriDepartment of Hematology University Tor Vergata Rome Italy.
Mario LuppiDepartment Medical and Surgical Sciences Section of Hematology Azienda Ospedaliero-Universitaria Policlinico University of Modena and Reggio Emilia Modena Italy.
Policlinico di Modena · ITUniversity of Modena and Reggio Emilia · ITUniversity of Rome Tor Vergata · ITOspedale Santa Maria · ITUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Based upon the clinical behavior of three patients, we suggest that the combination of low-dose Ara-C and all-trans retinoic acid may potentially be effective in some elderly patients, unfit for intensive chemotherapy, affected with

Indexed as

All‐trans retinoic acidelderly patientslow‐dose Ara‐CNPM1‐mutated acute myeloid leukemiaunfitness for intensive chemotherapy

Identifiers

PMID27980750
PMCPMC5134148
OpenAlexW2532683249

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.