ArticleThe World Allergy Organization journal2016
Local allergic rhinitis: entopy or spontaneous response?
Article in The World Allergy Organization journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Molecular Biomarkers in IgE Immunoassays Used for Grass Pollen Allergy Diagnosis in European Clinical Settings.International journal of molecular sciences · 2026Review
- From nasal cytology to cellular endotyping: mast cell-eosinophil interactions and overlapping inflammation in allergic rhinitis.Frontiers in immunology · 2026Review
- Diagnostic Workup in IgE-Mediated Allergy to Asteraceae Weed Pollen and Herbal Medicine Products in Europe.Medicina (Kaunas, Lithuania) · 2024Review
- [Immunoglobulin E in nasal secretions].HNO · 2024Review
- Challenges in Local Allergic Rhinitis Diagnosis, Management, and Research: Current Concepts and Future Perspectives.Medicina (Kaunas, Lithuania) · 2023Review
- Gold standard diagnostic algorithm for the differential diagnosis of local allergic rhinitis.Postepy dermatologii i alergologii · 2022Review
- The role of the nasal allergen provocation test in local allergic rhinitis cases: a preliminary report.Postepy dermatologii i alergologii · 2020Article
- Allergen Immunotherapy for Local Respiratory Allergy.Current allergy and asthma reports · 2020Review
- Local Allergic Rhinitis Revisited.Current allergy and asthma reports · 2020Review
- Local allergic conjunctivitis: a phenotype of allergic conjunctivitis.International ophthalmology · 2019Article
- How to Diagnose and Treat Local Allergic Rhinitis: A Challenge for Clinicians.Journal of clinical medicine · 2019Review
- Dilemmas associated with local allergic rhinitis.Postepy dermatologii i alergologii · 2018Review
- Eosinophils from Physiology to Disease: A Comprehensive Review.BioMed research international · 2018Review
- Is nonhomogeneous expression of tissue mast cells or allergen specific IgEs bound to tissue mast cells possible?Asia Pacific allergy · 2017Article
- Local allergic rhinitis: evolution of concepts.Clinical and translational allergy · 2017Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe existence of a local allergic rhintis was proposed on the basis of the detection of nasal IgE in the absence of a systemic sensitization. Nevertheless, the significance of this phenomenon remains still unclear. We assessed the presence of mucosal nasal IgE in patients with ascertained allergic rhinitis, nonallergic rhinitis with inflammation and in healthy controls.
methodsConsecutive patients with a well ascertained diagnosis (clinical history, skin prick test, specific IgE assay, nasal endoscopy, nasal cytology) underwent an immunoenzymatic measurement of specific IgE to grass, cypress, parietaria and olive in nasal scrapings.
resultsFifteen patients with allergic rhinitis, 12 with non allergic rhinitis and 14 healthy subjects were studied. The patients with allergic and nonallergic rhinitis had higher nasal symptoms as compared to control subjects. Systemic sensitizatition (assessed by skin test and CAP-RAST) was obviously more frequent in allergic rhinitis, than in the other two groups. Allergen-specific nasal IgE could be detected in all groups (86,7, 33,3, and 50 % positive, respectively), even more frequently in the control group than in nonallergic rhinitis patients. No difference among allergens was identified. Out of the 26 non-allergic patients (non allergic rhinitis + controls) nasal IgE were positive in 11(42 %). DISCUSSION: According to the results, the presence of nasal IgE against allergens seems to be a non-specific phenomenon, since they can be detected also in non allergic rhinitis and in healthy subjects.
conclusionIt can be hypothesized that the nasal IgE production represents a form of spontaneous immune response.
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