Evidence map›Paper›PMID 27980694›Full record

ArticleClinical epigenetics2016

A methylation PCR method determines

Andrew G Hadd, Stela Filipovic-Sadic, Lili Zhou, Arianna Williams, Gary J Latham, Elizabeth Berry-Kravis, Deborah A Hall

Open access · goldAbstract read
In one paragraph

Article in Clinical epigenetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Prodromal Markers of Upper Limb Deficits inMovement disorders clinical practice · 2020
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andrew G HaddResearch and Technology Development, Asuragen, Inc., Austin, TX 78744 USA.
Stela Filipovic-SadicResearch and Technology Development, Asuragen, Inc., Austin, TX 78744 USA.
Lili ZhouDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL USA ; Departments of Pediatrics and Biochemistry, Rush University Medical Center, Chicago, IL USA.
Arianna WilliamsDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL USA.
Gary J LathamResearch and Technology Development, Asuragen, Inc., Austin, TX 78744 USA.
Elizabeth Berry-KravisDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL USA ; Departments of Pediatrics and Biochemistry, Rush University Medical Center, Chicago, IL USA.
Deborah A HallDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL USA.
Rush University Medical Center · USAsuragen (United States) · US

Funding

Amplification Strategies for Detection of Fragile X Gene Trinucleotide RepeatsR44HD060450 · NICHD · AMBION DIAGNOSTICS, INC. · PI HADD, ANDREW G · 2010 to 2011
$1.2M
Prevalence of FMRI Expansions in Movement DisordersK23NS052487 · NINDS · UNIVERSITY OF COLORADO DENVER · PI HALL, DEBORAH A · 2006 to 2010
$881k
NICHD NIH HHS R44 HD060450NINDS NIH HHS K23 NS052487
6 · The paper itself

Abstract

backgroundEpigenetic modifications of the fragile X mental retardation 1 (

resultsActivation ratios (ARs) in 39 PM women were determined by mPCR and compared with SB analysis. ARs were distributed across a range of values including five samples with <20% AR and six with >80% AR. The two methods were correlated (

conclusionsWe utilized a repeatable and streamlined methodology to characterize

Indexed as

DNA MethylationAtaxiaEpigenesis, GeneticFemaleFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeGenetic Predisposition to DiseaseGenotypeHeterozygoteHumansMosaicismPolymerase Chain ReactionSiblingsTremorFMR1 protein, humanFragile X Messenger Ribonucleoprotein 1Activation ratioFMR1Fragile XMethylation PCRPremutationX-chromosome inactivation

Identifiers

PMID27980694
PMCPMC5131543
OpenAlexW2557698617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.