ArticleBMC proceedings2016
Comparing strategies for combined testing of rare and common variants in whole sequence and genome-wide genotype data.
Article in BMC proceedings, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gene-set meta-analysis of lung cancer identifies pathway related to systemic lupus erythematosus.PloS one · 2017Pooled it
- Relating drug response to epigenetic and genetic markers using a region-based kernel score test.BMC proceedings · 2018Article
- Pathway-Based Kernel Boosting for the Analysis of Genome-Wide Association Studies.Computational and mathematical methods in medicine · 2017Article
- Filtering genetic variants and placing informative priors based on putative biological function.BMC genetics · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We used our extension of the kernel score test to family data to analyze real and simulated baseline systolic blood pressure in extended pedigrees. We compared the power for different kernels and for different weightings of genetic markers. Moreover, we compared the power of rare and common markers with 3 strategies for joint testing and on marker panels with different densities. Marker weights had much greater influence on power than the kernel chosen. Inverse minor allele frequency weights often increased power on common markers but could decrease power on rare markers. Furthermore, defining the gene region based on linkage disequilibrium blocks often yielded robust power of joint tests of rare and common markers.
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Registered trials
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