ArticleClinical and experimental gastroenterology2016
Absorption and safety of serum-derived bovine immunoglobulin/protein isolate in healthy adults.
Article in Clinical and experimental gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Serum-Derived Bovine Immunoglobulin Promotes Barrier Integrity and Lowers Inflammation for 24 Human Adults Ex Vivo.Nutrients · 2024Article
- Article
- Multiprotein Adsorption from Human Serum at Gold and Oxidized Iron Surfaces Studied by Atomic Force Microscopy and Polarization-Modulation Infrared Reflection Absorption Spectroscopy.Molecules (Basel, Switzerland) · 2023Article
- Serum-Derived Bovine Immunoglobulin Stimulates SCFA Production by Specific Microbes in the Ex Vivo SIFRMicroorganisms · 2023Article
- Potential use of serum-derived bovine immunoglobulin/protein isolate for the management of COVID-19.Drug development research · 2021Article
- In Vitro Induction of Trained Innate Immunity by bIgG and Whey Protein Extracts.International journal of molecular sciences · 2020Article
- Intact anti-LPS IgY is found in the blood after intragastric administration in mice.FEBS open bio · 2019Article
- Serum-derived bovine immunoglobulin for children with diarrhea-predominant irritable bowel syndrome.Pediatric health, medicine and therapeutics · 2018Article
- Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection.Frontiers in nutrition · 2018Review
- Serum-Derived Bovine Immunoglobulin as Novel Adjunct in ComplicatedACG case reports journal · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePrevious studies have shown that oral administration of bovine immunoglobulin protein preparations is safe and provides nutritional and intestinal health benefits. The purpose of this study was to evaluate the plasma amino acid response following a single dose of serum-derived bovine immunoglobulin/protein isolate (SBI) and whether bovine immunoglobulin G (IgG) is present in stool or in blood following multiple doses of SBI in healthy volunteers.
methodsA total of 42 healthy adults were administered a single dose of placebo or SBI at one of three doses (5 g, 10 g, or 20 g) in blinded fashion and then continued on SBI (2.5 g, 5 g, or 10 g) twice daily (BID) for an additional 2 weeks. Serial blood samples were collected for amino acid analysis following a single dose of placebo or SBI. Stool and blood samples were collected to assess bovine IgG levels.
resultsThe area under the curve from time 0 minute to 180 minutes for essential and total amino acids as well as tryptophan increased following ingestion of 5 g, 10 g, or 20 g of SBI, with a significant difference between placebo and all doses of SBI (
conclusionOral administration of SBI leads to increases in plasma essential amino acids during transit through the gastrointestinal tract and is safe at levels as high as 20 g/day.
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