Evidence map›Paper›PMID 27980383›Full record

ArticleJournal of preventive medicine and hygiene2016

Using the cytokinesis-block micronucleus cytome assay to evaluate chromosomal DNA damage in chronic renal patients undergoing bicarbonate haemodialysis and haemodiafiltration.

M Guido, A Zizza, M R Tumolo, G Stefanelli, M D'Alba, A Idolo, F Bagordo, F Serio, T Grassi, A DE Donno

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Article in Journal of preventive medicine and hygiene, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

M GuidoLaboratory of Hygiene, Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.
A ZizzaInstitute of Clinical Physiology, National Research Council, Lecce, Italy.
M R TumoloInstitute of Clinical Physiology, National Research Council, Lecce, Italy.
G StefanelliNephrology & Dialysis Special Unit, "I. Veris Delli Ponti" Hospital, Scorrano, Lecce Local Health Unit, Italy.
M D'AlbaDialysis Special Unit, "F. Pispico" Hospital, Poggiardo, Lecce Local Health Unit, Italy.
A IdoloLaboratory of Hygiene, Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.
F BagordoLaboratory of Hygiene, Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.
F SerioLaboratory of Hygiene, Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.
T GrassiLaboratory of Hygiene, Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.
A DE DonnoLaboratory of Hygiene, Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.
University of Salento · ITIstituto di Fisiologia Clinica · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChronic Renal Failure (CRF) patients are considered to show genomic instability and are associated with a high risk of both cardiovascular diseases and cancer. We explored DNA damage due to two dialysis treatments in 20 patients undergoing bicarbonate haemodialysis (BD), 20 undergoing haemodiafiltration (HDF) and 40 healthy subjects.

methodsThe cytokinesis-block micronucleus (MN) assay was performed on peripheral blood lymphocytes to evaluate genetic damage.

resultsA higher frequency of MN in the dialysis groups compared with controls was found. The results do not show a relationship between genetic instability and the type, frequency and duration of haemodialysis. The average BD and HDF treatment time was respectively 3.8 ± 6.3 and 3.7 ± 3.9 yrs. CAT and scintigraphy was independently correlated with high levels of MN.

conclusionsOverall, the frequency of MN in CRF patients undergoing dialysis therapy was observed to be higher. Further studies need to be performed on a larger number of patients and for a longer period.

Indexed as

CytokinesisDNA DamageHemodiafiltrationMicronucleus TestsRenal DialysisBicarbonatesCase-Control StudiesHumansKidney Failure, ChronicBicarbonatesChronic Renal Failure (CRF)DNA damageMicronucleus (MN)

Identifiers

PMID27980383
PMCPMC5139614
OpenAlexW2560116523

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.