Evidence map›Paper›PMID 27980262›Full record

ArticleInternal medicine (Tokyo, Japan)

Expression of Extracellular Signal-regulated Kinase 5 and Ankyrin Repeat Domain 1 in Composite Pheochromocytoma and Ganglioneuroblastoma Detected Incidentally in the Adult Adrenal Gland.

Shinta Suenaga, Osamu Ichiyanagi, Hiromi Ito, Sei Naito, Tomoyuki Kato, Akira Nagaoka, Tomoya Kato, Mitsunori Yamakawa, Yutaro Obara, Norihiko Tsuchiya

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Shinta SuenagaDepartment of Urology, Yamagata University Faculty of Medicine, Japan.
Osamu Ichiyanagi
Hiromi Ito
Sei Naito
Tomoyuki Kato
Akira Nagaoka
Tomoya Kato
Mitsunori Yamakawa
Yutaro Obara
Norihiko Tsuchiya
Yamagata University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Composite pheochromocytoma (cPC) is extremely rare, arising in the adrenal medulla as a mixture of PC and other tumors of neural origin. We herein report on a case of adrenal incidentaloma post-operatively diagnosed as cPC with ganglioneuroblastoma (GNBL). The PC component had 7 points on the PASS, a Ki-67 index of 5.1%, a focal absence of sustentacular cells, and no genetic aberrations in succinate dehydrogenase subunit B. The GNBL component exhibited no N-myc amplification. Tumor cells of both components were stained positively for extracellular signal-regulated kinase 5 and ankyrin repeat domain 1. The aberrant activation of growth signaling may play a role in the marginal malignancy of cPC.

Indexed as

AdrenalectomyAdrenal Gland NeoplasmsAdrenal MedullaFemaleFollow-Up StudiesGanglioneuroblastomaHumansIncidental FindingsMiddle AgedMitogen-Activated Protein Kinase 7Muscle ProteinsNuclear ProteinsPheochromocytomaRepressor ProteinsSignal TransductionSuccinate DehydrogenaseANKRD1 protein, humanMAPK7 protein, humanMitogen-Activated Protein Kinase 7Muscle ProteinsNuclear ProteinsRepressor ProteinsSDHD protein, humanSuccinate Dehydrogenase

Identifiers

PMID27980262
PMCPMC5283962
OpenAlexW2562928244

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.