ArticleLearning & memory (Cold Spring Harbor, N.Y.)2017
Primary auditory cortex regulates threat memory specificity.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Neural mechanisms of fear memory precision and generalization: from auditory cortex to amygdala.Translational psychiatry · 2026Review
- Primary auditory cortex activity during early retrieval supports later extinction learning.Neurobiology of learning and memory · 2025Article
- Polyunsaturated fatty-acids diet increases fear discrimination in rats and IGF-2 receptors signaling in the auditory cortex.Scientific reports · 2025Article
- A disinhibitory microcircuit in the temporal association cortex for fear retrieval to pure tones.Scientific reports · 2025Article
- Safety learning induces postsynaptic potentiation of direct pathway spiny projection neurons in the tail of the striatum.bioRxiv : the preprint server for biology · 2025Article
- Auditory cortical neurons are recruited to encode fear signals and anxiety by neuroligin-3-mediated synapse formation.Translational psychiatry · 2025Article
- Alteration of neural activity and neuroinflammatory factors in the insular cortex of mice with corneal neuropathic pain.Genes, brain, and behavior · 2023Article
- Frequency-Dependent Plasticity in the Temporal Association Cortex Originates from the Primary Auditory Cortex, and Is Modified by the Secondary Auditory Cortex and the Medial Geniculate Body.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Brain Mapping the Effects of Chronic Aerobic Exercise in the Rat Brain Using FDG PET.Journal of personalized medicine · 2022Article
- Neuronal activity in sensory cortex predicts the specificity of learning in mice.Nature communications · 2022Article
- Basolateral amygdala to posterior piriform cortex connectivity ensures precision in learned odor threat.Scientific reports · 2021Article
- Absence Makes the Mind Grow Fonder: Reconceptualizing Studies of Safety Learning in Translational Research on Anxiety.Cognitive, affective & behavioral neuroscience · 2021Review
- A Novel Peripheral Action of PICK1 Inhibition in Inflammatory Pain.Frontiers in cellular neuroscience · 2021Article
- Precise memory for pure tones is predicted by measures of learning-induced sensory system neurophysiological plasticity at cortical and subcortical levels.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Visuocortical tuning to a threat-related feature persists after extinction and consolidation of conditioned fear.Scientific reports · 2020Article
- Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior.PLoS biology · 2019Article
- Article
- Coherent Activity between the Prelimbic and Auditory Cortex in the Slow-Gamma Band Underlies Fear Discrimination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Article
- Associative Learning of Stimuli Paired and Unpaired With Reinforcement: Evaluating Evidence From Maggots, Flies, Bees, and Rats.Frontiers in psychology · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Distinguishing threatening from nonthreatening stimuli is essential for survival and stimulus generalization is a hallmark of anxiety disorders. While auditory threat learning produces long-lasting plasticity in primary auditory cortex (Au1), it is not clear whether such Au1 plasticity regulates memory specificity or generalization. We used muscimol infusions in rats to show that discriminatory threat learning requires Au1 activity specifically during memory acquisition and retrieval, but not during consolidation. Memory specificity was similarly disrupted by infusion of PKMζ inhibitor peptide (ZIP) during memory storage. Our findings show that Au1 is required at critical memory phases and suggest that Au1 plasticity enables stimulus discrimination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.