ArticleProceedings of the National Academy of Sciences of the United States of America2017
Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
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Who cites it
49 citing papers in PubMed, 73 citations in OpenAlex.
- Convergent strategies for nanobody-mediated inhibition of an epoxide hydrolase.bioRxiv : the preprint server for biology · 2026Article
- Pro-resolving lipid mediators in diseases: exploring the molecular basis and clinical implication.Molecular biomedicine · 2026Review
- Impact of overexpression of wild-type CFTR and elexacaftor-tezacaftor-ivacaftor on oxylipin production by the CFBE41o- bronchial epithelial cell line.Prostaglandins & other lipid mediators · 2025Article
- Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic Cardiomyopathy.JACC. Basic to translational science · 2025Article
- Proresolving Lipid Mediators in the Respiratory System.Annual review of physiology · 2025Review
- The relationship between ferroptosis and respiratory infectious diseases: a novel landscape for therapeutic approach.Frontiers in immunology · 2025Review
- Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in Pseudomonas aeruginosa.Nucleic acids research · 2024Article
- Neutrophil Infiltration and Function in the Pathogenesis of Inflammatory Airspace Disease.The American journal of pathology · 2024Review
- Lipoxygenases at the Intersection of Infection and Carcinogenesis.International journal of molecular sciences · 2024Review
- Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic Cardiomyopathy.bioRxiv : the preprint server for biology · 2024Article
- Enhancing cancer immunotherapy via inhibition of soluble epoxide hydrolase.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit inbioRxiv : the preprint server for biology · 2024Article
- Article
- Article
- The changing landscape of the cystic fibrosis lung environment: From the perspective of Pseudomonas aeruginosa.Current opinion in pharmacology · 2022Review
- Failed Eradication Therapy of New-Onset Pseudomonas aeruginosa Infections in Children With Cystic Fibrosis Is Associated With Bacterial Resistance to Neutrophil Functions.The Journal of infectious diseases · 2022Article
- P. aeruginosa augments irradiation injury via 15-lipoxygenase-catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis.JCI insight · 2022Article
- Eicosanoid regulation of debris-stimulated metastasis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Lipid-Derived Mediators are Pivotal to Leukocyte and Lung Cell Responses in Sepsis and ARDS.Cell biochemistry and biophysics · 2021Review
- Role of specialized pro-resolving lipid mediators in pulmonary inflammation diseases: mechanisms and development.Respiratory research · 2021Review
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 1 country.
Becca A FlitterDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219.
Kelli L HvorecnyDepartment of Biochemistry & Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.
Emiko OnoPulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Taylor EddensDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224.
Jun YangDepartment of Entomology and Nematology and Comprehensive Cancer Center, University of California, Davis, CA 95616.
Daniel H KwakDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260.
Christopher D BahlDepartment of Biochemistry & Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.
Thomas H HamptonDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.
Christophe MorisseauDepartment of Entomology and Nematology and Comprehensive Cancer Center, University of California, Davis, CA 95616.
Bruce D HammockDepartment of Entomology and Nematology and Comprehensive Cancer Center, University of California, Davis, CA 95616.
Xinyu LiuDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260.
Janet S LeeDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213.
Jay K KollsDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224.
Bruce D LevyPulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Dean R MaddenDepartment of Biochemistry & Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755; jbomb@pitt.edu drm0001@dartmouth.edu.
Jennifer M BombergerDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219; jbomb@pitt.edu drm0001@dartmouth.edu.
University of Pittsburgh · USDartmouth College · USUniversity of California, Davis · USBrigham and Women's Hospital · US
Funding
Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1987 to 2021
$50.1MUnderstanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2016 to 2025
$25.9MResolution Mechanisms in Acute Inflammation: Resolution PharmacologyP01GM095467 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 2011 to 2020
$14.8MTranslational StudiesP30DK072506 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PILEWSKI, JOSEPH MARK · 2005 to 2017
$12.5MWest Coast Central Comprehensive Metabolomics Resource Core (WC3MRC)U24DK097154 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2012 to 2017
$9.9MMolecular and Cellular Biology at DartmouthT32GM008704 · NIGMS · DARTMOUTH COLLEGE · PI COMPTON, DUANE A. · 1998 to 2018
$6.8MTRANSLATIONAL RESEARCH COREP30GM106394 · NIGMS · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2013 to 2017
$6.1MImmunology of Infectious DiseaseT32AI060525 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JoAnne L. Flynn · 2005 to 2026
$5.3MRed Cell Tranfusion: Modifier of Lung and Systemic Inflammatory ResponsesR01HL086884 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, JANET SOJUNG · 2007 to 2017
$4.0MHYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINSR01ES002710 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1985 to 2018
$4.0MMechanism of Cif Virulence: A Bacterial Strategy to Subvert Host-Cell DefensesR01AI091699 · NIAID · DARTMOUTH COLLEGE · PI MADDEN, DEAN R, O'TOOLE, GEORGE A. · 2012 to 2016
$2.3MMonitoring peripheral blood leukocyte and immune responses in health and diseaseU24AI118656 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LEVY, BRUCE D, VOLDMAN, JOEL · 2015 to 2019
$1.9MNHLBI NIH HHS R00 HL098342NHLBI NIH HHS R01 HL086884NHLBI NIH HHS R01 HL123771NIAID NIH HHS R01 AI091699NIAID NIH HHS R21 AI119042NIAID NIH HHS T32 AI060525NIAID NIH HHS U24 AI118656NIDDK NIH HHS P30 DK072506NIDDK NIH HHS U24 DK097154NIEHS NIH HHS P42 ES004699NIEHS NIH HHS R01 ES002710NIGMS NIH HHS P01 GM095467NIGMS NIH HHS P20 GM113132NIGMS NIH HHS P30 GM106394NIGMS NIH HHS T32 GM008704
Abstract
Recurrent Pseudomonas aeruginosa infections coupled with robust, damaging neutrophilic inflammation characterize the chronic lung disease cystic fibrosis (CF). The proresolving lipid mediator, 15-epi lipoxin A
Indexed as
8,11,14-Eicosatrienoic AcidBacterial ProteinsBronchoalveolar Lavage FluidCell LineCrystallography, X-RayCystic FibrosisHumansInflammationLipoxinsLung DiseasesNeutrophil ActivationNeutrophilsPseudomonas aeruginosaPseudomonas InfectionsRetrospective StudiesVirulence Factors14,15-epoxy-5,8,11-eicosatrienoic acid8,11,14-Eicosatrienoic AcidBacterial ProteinsCif protein, Pseudomonas aeruginosalipoxin A4LipoxinsVirulence Factorscystic fibrosisepoxide hydrolaseinflammationlipoxinPseudomonas aeruginosa
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