ArticleJournal of the American Society of Nephrology : JASN2017
Dementia and Alzheimer's Disease among Older Kidney Transplant Recipients.
Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 65 citations in OpenAlex.
- Neighborhood Disadvantage and Dementia Risk Among Older Patients With Kidney Failure: Differences by Race/Ethnicity and Urbanicity.Kidney medicine · 2026Article
- Neighborhood Ambient Air Pollution and Post-Transplant Outcomes in Older Kidney Transplant Recipients.Journal of the American Geriatrics Society · 2026Article
- Assessing and cataloguing cognitive impairment in older potential kidney transplant patients: key recommendations from the ethical and legal issues working group of ELPAT.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Ambient Air Pollution, Cognitive Impairment, and Dementia Among Older Patients Being Evaluated for Kidney Transplantation.Clinical transplantation · 2025Article
- Sleep disorders and sleep medications as risk factors for dementia in kidney transplant recipients: A retrospective cohort study.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025Article
- Review
- Decoding subphenotypes in electronic medical records within late-onset Alzheimer's disease reveals heterogeneity and sex-specific differences.medRxiv : the preprint server for health sciences · 2025Article
- Economic Impact of Dementia After Kidney Transplantation: A Matched Cohort Analysis.Clinical transplantation · 2025Article
- Cognitive impairment in CKD patients: a guidance document by the CONNECT network.Clinical kidney journal · 2025Review
- Crosstalk of kidney and brain in diabetes-related cognitive impairment and therapeutic strategies.Frontiers in endocrinology · 2025Review
- Hospitalization and Hospitalized Delirium Are Associated With Decreased Access to Kidney Transplantation and Increased Risk of Waitlist Mortality.Clinical transplantation · 2024Article
- How to make a shared decision with older persons for end-stage kidney disease treatment: the added value of geronto-nephrology.Clinical kidney journal · 2024Review
- Residential Racial and Ethnic Segregation and Post-Kidney Transplant Dementia, Allograft Loss, and Mortality.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Article
- Incident dementia in kidney transplantation recipients: a matched comparative nationwide cohort study in South Korea.Kidney research and clinical practice · 2023Article
- Sleep duration and cognitive function among older adults with chronic kidney disease: results from the National Health and Nutrition Examination Survey (2011-2014).Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
- Long-term cognitive impairments in kidney transplant recipients: impact on participation and quality of life.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
- Screening of cognitive performance in kidney transplant recipients: a mini review.Frontiers in nephrology · 2023Review
- Delirium, changes in cognitive function, and risk of diagnosed dementia after kidney transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- Secondary hyperparathyroidism (CKD-MBD) treatment and the risk of dementia.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- Neuropsychological Assessment of Cognitive Impairment in Kidney Transplantation (NAsKiT) and its related risk factors: a study protocol.Journal of nephrology · 2022Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Older patients with ESRD who receive a kidney transplant (KT) may develop post-KT dementia and Alzheimer's disease (AD) associated with their long-standing kidney disease and/or neurotoxic immunosuppressant agents. To investigate this possibility, we studied 40,918 older (aged ≥55 years) KT recipients (January 1, 1999 to December 31, 2011) linked to Medicare claims through the US Renal Data System. We estimated dementia and AD risk (cumulative incidence) and studied factors associated with these sequelae using competing risks models. We estimated the risk of death-censored graft loss and mortality after developing dementia or the AD subtype of dementia, separately, using adjusted Cox proportional hazards models. Older recipients had a 10-year dementia risk ranging from 5.1% for recipients aged 55-60 years to 17.0% for recipients aged ≥75 years; 10-year AD risk ranged from 1.0% to 6.7%, respectively. The strongest predictors for dementia and AD were older recipient age and pretransplant diabetes. The 10-year graft loss risk was 28.8% for those who did not develop dementia and 43.1% for those who did, and the corresponding mortality risks were 55.7% and 89.9%, respectively. Older recipients with dementia had a 1.52-fold (95% confidence interval, 1.39 to 1.68) increased risk of graft loss and a 2.38-fold (95% confidence interval, 2.26 to 2.49) increased risk of mortality. We observed similar results for AD. We conclude that older KT recipients have a high risk of post-KT dementia and AD, and these sequelae associate with a profound effect on patient and graft survival.
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Registered trials
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