ArticleCirculation. Arrhythmia and electrophysiology2016
Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension.
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Article in Circulation. Arrhythmia and electrophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- The mechanism of m6A modification in cardiovascular diseases: A systematic review.Genes & diseases · 2026Review
- Bradycardias in Patients with Pulmonary Hypertension-Prevalence, Pathophysiology and Clinical Relevance.Journal of cardiovascular development and disease · 2025Article
- Up-regulated expression of two-pore domain KFrontiers in cardiovascular medicine · 2024Article
- Beta Blockade Prevents Cardiac Morphological and Molecular Remodelling in Experimental Uremia.International journal of molecular sciences · 2023Article
- Remodelling and dysfunction of the sinus node in pulmonary arterial hypertension.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Review
- Right Heart Failure in a Patient with Critical Pulmonary Stenosis, Absent Right Pulmonary Artery, and Lung Cancer.The American journal of case reports · 2022Article
- Transcriptomic profile of cationic channels in human pulmonary arterial hypertension.Scientific reports · 2021Article
- Importance of Cx43 for Right Ventricular Function.International journal of molecular sciences · 2021Review
- Echocardiographic, Biochemical, and Electrocardiographic Correlates Associated With Progressive Pulmonary Arterial Hypertension.Frontiers in cardiovascular medicine · 2021Article
- Cardiac Pacemaker Dysfunction Arising From Different Studies of Ion Channel Remodeling in the Aging Rat Heart.Frontiers in physiology · 2020Article
- Animal models of arrhythmia: classic electrophysiology to genetically modified large animals.Nature reviews. Cardiology · 2019Review
- Intra-tracheal gene delivery of aerosolized SERCA2a to the lung suppresses ventricular arrhythmias in a model of pulmonary arterial hypertension.Journal of molecular and cellular cardiology · 2019Article
- Article
- Article
- Isolated heart model demonstrates evidence of contractile and diastolic dysfunction in right ventricles from rats with sugen/hypoxia-induced pulmonary hypertension.Physiological reports · 2017Article
Corrections and comments
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Authors and funding
23 authors at 2 institutions in 2 countries.
Ian P TempleFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Sunil Jit R J LoganthaFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Mais AbsiFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Yu ZhangFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Eleftheria PervolarakiFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Joseph YanniFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Andrew AtkinsonFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Maria PetkovaFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Gillian M QuigleyFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Simon CastroFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Mark DrinkhillFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Heiko SchneiderFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Oliver MonfrediFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Elizabeth CartwrightFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Min ZiFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Tomoko T YamanushiFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Vaikom S MahadevanFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Alison M GurneyFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Ed WhiteFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Henggui ZhangFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
George HartFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
Mark R BoyettFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.). mark.boyett@manchester.ac.uk.
Halina DobrzynskiFrom the Institute of Cardiovascular Sciences (I.P.T., S.J.R.J.L., M.A., Y.Z., J.Y., A.A., M.P., G.M.Q., H.S., O.M., E.C., M.Z., A.M.G., G.H., M.R.B., H.D.) and School of Physics and Astronomy (S.C., H.Z.), University of Manchester, United Kingdom; School of Biomedical Sciences, University of Leeds, United Kingdom (E.P., M.D., E.W.); Kagawa Prefectural College of Health Sciences, Takamatsu, Japan (T.T.Y.); and Department of Medicine, University of California, San Francisco (V.S.M.).
University of Leeds · GBKagawa Prefectural College of Health Sciences · JP
Funding
British Heart Foundation FS/10/69/28495British Heart Foundation PG/13/3/29924British Heart Foundation PG/14/22/30714British Heart Foundation RG/11/18/29257
Abstract
backgroundHeart block is associated with pulmonary hypertension, and the aim of the study was to test the hypothesis that the heart block is the result of a change in the ion channel transcriptome of the atrioventricular (AV) node. METHODS AND
resultsThe most commonly used animal model of pulmonary hypertension, the monocrotaline-injected rat, was used. The functional consequences of monocrotaline injection were determined by echocardiography, ECG recording, and electrophysiological experiments on the Langendorff-perfused heart and isolated AV node. The ion channel transcriptome was measured by quantitative PCR, and biophysically detailed computer modeling was used to explore the changes observed. After monocrotaline injection, echocardiography revealed the pattern of pulmonary artery blood flow characteristic of pulmonary hypertension and right-sided hypertrophy and failure; the Langendorff-perfused heart and isolated AV node revealed dysfunction of the AV node (eg, 50% incidence of heart block in isolated AV node); and quantitative PCR revealed a widespread downregulation of ion channel and related genes in the AV node (eg, >50% downregulation of Ca
conclusionsPulmonary hypertension results in a derangement of the ion channel transcriptome in the AV node, and this is the likely cause of AV node dysfunction in this disease.
Indexed as
TranscriptomeAnimalsAtrioventricular NodeDisease Models, AnimalDown-RegulationEchocardiographyElectrocardiographyElectrophysiologic Techniques, CardiacHeart BlockHypertension, PulmonaryIon ChannelsMaleMonocrotalinePolymerase Chain ReactionRatsRats, WistarIon ChannelsMonocrotalineatrioventricular nodeechocardiographyheart blockion channelstranscriptome
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