Evidence map›Paper›PMID 27979861›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2017

BMI-1 extends proliferative potential of human bronchial epithelial cells while retaining their mucociliary differentiation capacity.

Mustafa M Munye, Amelia Shoemark, Robert A Hirst, Juliette M Delhove, Tyson V Sharp, Tristan R McKay, Christopher O'Callaghan, Deborah L Baines, Steven J Howe, Stephen L Hart

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 48 citations in OpenAlex.

  1. Preclinical human models of primary ciliary dyskinesia.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  2. Utilising human cellular models of primary ciliary dyskinesia: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2026
    Article
  3. Article
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  5. PathogeniciScience · 2025
    Article
  6. Article
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  8. Molecular and functional correction of a deep intronic splicing mutation inMolecular therapy. Methods & clinical development · 2023
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. PCD Genes-From Patients to Model Organisms and Back to Humans.International journal of molecular sciences · 2022
    Review
  15. Article
  16. Human models for COVID-19 research.The Journal of physiology · 2021
    Article
  17. Article
  18. Stem Cell-derived Respiratory Epithelial Cell Cultures as Human Disease Models.American journal of respiratory cell and molecular biology · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Mustafa M MunyeUniversity College London Great Ormond Street Institute of Child Health, London, United Kingdom.
Amelia ShoemarkImperial College London, UK Electron Microscopy Department, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.
Robert A HirstPrimary Ciliary Dyskinesia Centre Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
Juliette M DelhoveUniversity College London Great Ormond Street Institute of Child Health, London, United Kingdom.
Tyson V SharpCentre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.
Tristan R McKaySchool of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom; and.
Christopher O'CallaghanUniversity College London Great Ormond Street Institute of Child Health, London, United Kingdom.
Deborah L BainesInstitute for Infection and Immunity, St George's, University of London, London, United Kingdom.
Steven J HoweUniversity College London Great Ormond Street Institute of Child Health, London, United Kingdom.
Stephen L HartUniversity College London Great Ormond Street Institute of Child Health, London, United Kingdom; s.hart@ucl.ac.uk.
University College London · GBGreat Ormond Street Hospital · GBImperial College London · GBManchester Metropolitan University · GBQueen Mary University of London · GBSt George's, University of London · GBUniversity of Leicester · GB

Funding

Cancer Research UK 12733Medical Research Council MR/K012770/1Medical Research Council MR/N009185/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/L001780/1
6 · The paper itself

Abstract

Air-liquid interface (ALI) culture of primary airway epithelial cells enables mucociliary differentiation providing an in vitro model of the human airway, but their proliferative potential is limited. To extend proliferation, these cells were previously transduced with viral oncogenes or mouse

Indexed as

Cell DifferentiationAnimalsAxonemal DyneinsBronchiCell ProliferationCell ShapeCiliaCyclin-Dependent Kinase Inhibitor p16DyneinsElectric ImpedanceElectrophysiological PhenomenaEpithelial CellsGene Knockdown TechniquesHEK293 CellsHumansKartagener SyndromeAxonemal DyneinsBMI1 protein, humanCyclin-Dependent Kinase Inhibitor p16DNAH5 protein, humanDyneinsPolycomb Repressive Complex 1air-liquid interfaceairway modellungmucociliary differentiationprimary ciliary dyskinesia

Identifiers

PMID27979861
PMCPMC5336581
OpenAlexW2565664497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.