Observational studyBMJ open2016
Relation between carotid stiffness, cognitive performance and brain connectivity in a healthy middle-aged population: an observational neurophysiological cohort study with magnetoencephalography.
Observational study in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- The influence of aortic stiffness on carotid stiffness: computational simulations using a human aorta carotid model.Royal Society open science · 2024Article
- Effects of Carotid Artery Stiffness on Cerebral Small-Vessel Disease and Cognition.Journal of the American Heart Association · 2022Article
- Cognitive Impairment in Long-Term Survivors of Testicular Cancer More Than 20 Years after Treatment.Cancers · 2021Article
- Carotid Artery Blood Flow Velocities and Cognitive Performance: Forecasting Cognitive Decline.American journal of hypertension · 2019Article
- Consistency of magnetoencephalographic functional connectivity and network reconstruction using a template versus native MRI for co-registration.Human brain mapping · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveImpaired blood flow of the carotid artery can result in cognitive impairment, but how these vascular impairments lead to global cognitive disturbances is largely unknown. Problems in functional connectivity between brain areas may be responsible for these widespread effects. Therefore, the aim of this study was to examine the association between carotid stiffness, functional connectivity and cognitive performance in relatively young and healthy adults before clinical vascular pathology occurs.
designThe Amsterdam Growth and Health Longitudinal Study: an observational study.
settingParticipants were included by attending 1 of the 2 selected secondary schools in The Netherlands.
participantsMen (n=110) and women (n=120) aged 41-44 years (42±0.7). PRIMARY AND SECONDARY OUTCOME MEASURES: Data were obtained with regard to local carotid stiffness captured measured with the Young's elastic modulus (YEM). All participants underwent a commonly used Dutch intelligence test and resting-state eyes-closed magnetoencephalography (MEG). Five artefact-free epochs were analysed. The phase lag index (PLI) was used as a measure of functional connectivity between all sensors and was assessed in six frequency bands (δ-γ).
resultsCarotid stiffness was significantly associated with increased functional connectivity in the α2 band in men (β: 0.287; p=0.008). The same results were found for women in the β band (β: 0.216; p=0.040). Furthermore, carotid stiffness was associated with superior cognitive function in men (β: 0.238; p=0.007). In addition, there was neither a significant association nor a consistent pattern between cognitive function and functional connectivity.
conclusionsThe increased connectivity might be a maladaptive phenomenon caused by disinhibition of neurons which may explain the direction of the results. This study suggests that detection of increased (local) carotid stiffness may be promising to identify a disturbance in the organisation of the functional brain network, even before clinical vascular pathology occurs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.