Evidence map›Paper›PMID 27979836›Full record

ArticleBMJ open2016

Longitudinal study of cardiometabolic risk from early adolescence to early adulthood in an ethnically diverse cohort.

Seeromanie Harding, Maria João Silva, Oarabile R Molaodi, Zinat E Enayat, Aidan Cassidy, Alexis Karamanos, Ursula M Read, J Kennedy Cruickshank

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03283332 (Determinants of Adolescent Social Well-being and Health), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03283332 completednot on this map

Determinants of Adolescent Social Well-being and Health: a London Based Longitudinal Study of Young People From Different Ethnic Groups

TypeobservationalSponsorKing's College LondonRan2011 to 2012Enrolled6,643ConditionsCardiovascular Risk FactorArmsNo intervention
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Review
  5. Article
  6. Article
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Seeromanie HardingCardiovascular Medicine & Social Epidemiology Group, Division of Diabetes & Nutritional Sciences, King's College London, London, UK.
Maria João SilvaCardiovascular Medicine & Social Epidemiology Group, Division of Diabetes & Nutritional Sciences, King's College London, London, UK.
Oarabile R MolaodiMRC/CSO Social and Public Health Sciences Unit, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Zinat E EnayatNational Hospital for Neurology and Neurosurgery, University College London Hospitals, London, UK.
Aidan CassidyMRC/CSO Social and Public Health Sciences Unit, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Alexis KaramanosDepartment of Epidemiology and Health, ESRC International Centre for Lifecourse Studies in Society and Health, University College London, London, UK.
Ursula M ReadCERMES3 (Centre de Recherche Médecine, Sciences, Santé, Santé Mentale et Société), Université Paris Descartes, EHESS, CNRS UMR 8211, INSERM U988, Paris, France.
J Kennedy CruickshankCardiovascular Medicine & Social Epidemiology Group, Division of Diabetes & Nutritional Sciences, King's College London, London, UK.
King's College London · GBCentre National de la Recherche Scientifique · FRMRC/CSO Social and Public Health Sciences Unit · GBNational Hospital for Neurology and Neurosurgery · GBUniversity College London · GBUniversity of Glasgow · GB

Funding

Chief Scientist Office SPHSU1Medical Research Council 0.13039/N4 501100000265Medical Research Council MC_EX_G0701943Medical Research Council MC_U130015185Medical Research Council MC_UU_12017/1Medical Research Council MC_UU_12017/13Medical Research Council MR/N015959/1
6 · The paper itself

Abstract

objectiveTo examine influences of adiposity from early adolescence to early 20s on cardiovascular disease (CVD) risk in the multiethnic Determinants of young Adult Social well-being and Health (DASH) longitudinal study.

methodsIn 2002-2003, 6643 11-13-year-olds from 51 London schools participated at baseline, and 4785 were seen again at 14-16 years. Recently, 665 (97% of invited) participated in pilot follow-up at 21-23 years, with biological and psychosocial measures and blood biomarkers (only at 21-23 years). Regression models examined interplay between ethnicity, adiposity and CVD.

resultsAt 21-23 years, ∼30-40% were overweight. About half of the sample had completed a degree with little ethnic variation despite more socioeconomic disadvantage in adolescence among ethnic minorities. Regardless of ethnicity, overweight increased more steeply between 14-16 years and 21-23 years than between 11-13 years and 14-16 years. More overweight among Black Caribbean and Black African females, lower systolic blood pressure (sBP) among Indian females and Pakistani/Bangladeshi males compared with White UK peers, persisted from 11-13 years. At 21-23 years, glycated haemoglobin (HbA1c) was higher among Black Caribbean females, total cholesterol higher and high-density lipoprotein (HDL) cholesterol lower among Pakistani/Bangladeshis. Overweight was associated with a ∼+2 mm Hg rise in sBP between 11-13 years and 21-23 years. Adiposity measures at 11-13 years were related to allostatic load (a cluster of several risk markers), HbA1c and HDL cholesterol at 21-23 years. Ethnic patterns in CVD biomarkers remained after adjustments.

conclusionsAdolescent adiposity posed significant risks at 21-23 years, a period in the lifespan generally ignored in cardiovascular studies, when ethnic/gender variations in CVD are already apparent.

Indexed as

AdiposityAsian PeopleBlack PeopleEthnicityWhite PeopleAdipose TissueAdolescentAfricaAsia, WesternBiomarkersBlood PressureCardiovascular DiseasesCaribbean RegionCholesterol, HDLFemaleGlycated HemoglobinBiomarkersCholesterol, HDLGlycated Hemoglobinadolescencecohortethnicitygrowthlater CVD riskoverweight

Identifiers

PMID27979836
PMCPMC5223645
OpenAlexW2586955231

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.