Evidence map›Paper›PMID 27979828›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2017

Conditional genetic deletion of Ano1 in interstitial cells of Cajal impairs Ca

John Malysz, Simon J Gibbons, Siva A Saravanaperumal, Peng Du, Seth T Eisenman, Chike Cao, Uhtaek Oh, Dieter Saur, Sabine Klein, Tamas Ordog and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 88 citations in OpenAlex.

  1. Pacemaking in the lymphatic system.The Journal of physiology · 2026
    Review
  2. Article
  3. Article
  4. Review
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  6. Article
  7. Review
  8. Article
  9. Article
  10. CaPhysiological reviews · 2024
    Review
  11. Article
  12. Review
  13. Calcium image analysis in the moving gut.Neurogastroenterology and motility · 2023
    Article
  14. Article
  15. Article
  16. A NovelJPGN reports · 2023
    Article
  17. Vascular mechanotransduction.Physiological reviews · 2023
    Review
  18. Reduced Expression of TMEM16A Impairs Nitric Oxide-Dependent ClFrontiers in cellular neuroscience · 2022
    Article
  19. Article
  20. CaCell calcium · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

John MalyszEnteric NeuroScience Program, Mayo Clinic, Rochester, Minnesota.
Simon J GibbonsEnteric NeuroScience Program, Mayo Clinic, Rochester, Minnesota.ORCID http://orcid.org/0000-0001-5311-5993
Siva A SaravanaperumalEnteric NeuroScience Program, Mayo Clinic, Rochester, Minnesota.
Peng DuAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Seth T EisenmanEnteric NeuroScience Program, Mayo Clinic, Rochester, Minnesota.
Chike CaoEnteric NeuroScience Program, Mayo Clinic, Rochester, Minnesota.
Uhtaek OhSensory Research Center, CRI, College of Pharmacy, Seoul National University, Seoul, Republic of Korea; and.
Dieter SaurDepartment of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Sabine KleinDepartment of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Tamas OrdogEnteric NeuroScience Program, Mayo Clinic, Rochester, Minnesota.
Gianrico FarrugiaEnteric NeuroScience Program, Mayo Clinic, Rochester, Minnesota; farrugia.gianrico@mayo.edu.
Mayo Clinic · USTUM Klinikum · DESeoul National University · KRUniversity of Auckland · NZ

Funding

PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI GREGORY J. GORES · 2009 to 2026
$22.2M
CALCIUM DYNAMICS IN INTERSTITIAL CELLS OF CAJALR01DK057061 · NIDDK · MAYO CLINIC ROCHESTER · PI GIANRICO FARRUGIA, Tamas Ordog · 2000 to 2026
$8.2M
Interstitial Cells of Cajal in Diabetic GastropathyR01DK058185 · NIDDK · UNIVERSITY OF NEVADA RENO · PI ORDOG, TAMAS · 2002 to 2020
$5.2M
MAMMALIAN TRANSPOSONSZ01DK057601 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI FURANO, ANTHONY V. · 1997 to 2008
$767k
Intramural NIH HHS Z01 DK057601NIDDK NIH HHS P30 DK084567NIDDK NIH HHS R01 DK057061NIDDK NIH HHS R01 DK058185
6 · The paper itself

Abstract

Myenteric plexus interstitial cells of Cajal (ICC-MY) in the small intestine are Kit

Indexed as

AnimalsAnoctamin-1CalciumCalcium SignalingChloride ChannelsInterstitial Cells of CajalIntestine, SmallMiceMice, TransgenicMuscle, SmoothMyenteric PlexusANO1 protein, mouseAnoctamin-1CalciumChloride ChannelsanoctaminCa2+ transientsgenetic knockoution channelpacemakerslow wave

Identifiers

PMID27979828
PMCPMC5401988
OpenAlexW2567214527

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.