Evidence map›Paper›PMID 27979807›Full record

ArticleJournal of the American Heart Association2016

Clinical and Epidemiological Implications of 24-Hour Ambulatory Blood Pressure Monitoring for the Diagnosis of Hypertension in Kenyan Adults: A Population-Based Study.

Anthony O Etyang, Ben Warne, Sailoki Kapesa, Kenneth Munge, Evasius Bauni, J Kennedy Cruickshank, Liam Smeeth, J Anthony G Scott

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
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  11. Mapping the Current and Future Noncommunicable Disease Burden in Kenya by Human Immunodeficiency Virus Status: A Modeling Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Anthony O EtyangKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya aetyang@kemri-wellcome.org.
Ben WarneKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Sailoki KapesaKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Kenneth MungeKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Evasius BauniKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
J Kennedy CruickshankKing's College, London, United Kingdom.
Liam SmeethLondon School of Hygiene and Tropical Medicine, London, United Kingdom.
J Anthony G ScottKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Kenya Medical Research Institute · KEWellcome Trust · GBLondon School of Hygiene & Tropical Medicine · GBThe King's College · US

Funding

Medical Research Council MR/K006584/1Wellcome TrustWellcome Trust 098504Wellcome Trust 098532Wellcome Trust 103951/Z/14/Z
6 · The paper itself

Abstract

backgroundThe clinical and epidemiological implications of using ambulatory blood pressure monitoring (ABPM) for the diagnosis of hypertension have not been studied at a population level in sub-Saharan Africa. We examined the impact of ABPM use among Kenyan adults. METHODS AND

resultsWe performed a nested case-control study of diagnostic accuracy. We selected an age-stratified random sample of 1248 adults from the list of residents of the Kilifi Health and Demographic Surveillance System in Kenya. All participants underwent a screening blood pressure (BP) measurement. All those with screening BP ≥140/90 mm Hg and a random subset of those with screening BP <140/90 mm Hg were invited to undergo ABPM. Based on the 2 tests, participants were categorized as sustained hypertensive, masked hypertensive, "white coat" hypertensive, or normotensive. Analyses were weighted by the probability of undergoing ABPM. Screening BP ≥140/90 mm Hg was present in 359 of 986 participants, translating to a crude population prevalence of 23.1% (95% CI 16.5-31.5%). Age standardized prevalence of screening BP ≥140/90 mm Hg was 26.5% (95% CI 19.3-35.6%). On ABPM, 186 of 415 participants were confirmed to be hypertensive, with crude prevalence of 15.6% (95% CI 9.4-23.1%) and age-standardized prevalence of 17.1% (95% CI 11.0-24.4%). Age-standardized prevalence of masked and white coat hypertension were 7.6% (95% CI 2.8-13.7%) and 3.8% (95% CI 1.7-6.1%), respectively. The sensitivity and specificity of screening BP measurements were 80% (95% CI 73-86%) and 84% (95% CI 79-88%), respectively. BP indices and validity measures showed strong age-related trends.

conclusionsScreening BP measurement significantly overestimated hypertension prevalence while failing to identify ≈50% of true hypertension diagnosed by ABPM. Our findings suggest significant clinical and epidemiological benefits of ABPM use for diagnosing hypertension in Kenyan adults.

Indexed as

Age DistributionBlood Pressure Monitoring, AmbulatoryCase-Control StudiesEarly DiagnosisFemaleHumansHypertensionKenyaMaleMiddle AgedPrevalenceambulatory blood pressure monitoringdiagnostic accuracyhypertensionmasked hypertensionsub‐Saharan Africawhite coat hypertension

Identifiers

PMID27979807
PMCPMC5210452
OpenAlexW2563884091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.