ArticleThe Journal of pediatrics2017
Safety and Short-Term Outcomes of Therapeutic Hypothermia in Preterm Neonates 34-35 Weeks Gestational Age with Hypoxic-Ischemic Encephalopathy.
Article in The Journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Systematic review of terminology, definitions, and eligibility criteria in trials of neonatal encephalopathy, hypoxic-ischemic encephalopathy, and perinatal asphyxia.Pediatric research · 2026Pooled it
- Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies.International journal of molecular sciences · 2021Pooled it
- Pharmacokinetics of morphine in encephalopathic neonates treated with therapeutic hypothermia.PloS one · 2019Trial
- Clinical practice guidelines for neonatal therapeutic hypothermia across European Society for Paediatric and Neonatal Intensive Care (ESPNIC) member countries: a multidisciplinary blind comparison.The Lancet regional health. Europe · 2026Article
- Neonatal encephalopathy mortality rate in Aotearoa, New Zealand: review of national data 2010-2020.BMJ paediatrics open · 2026Article
- Whole-body hypothermia in late preterm and early term infants: a retrospective analysis from a neurocritical care unit.Pediatric research · 2026Article
- Therapeutic hypothermia in infants <36 weeks gestation: proceed with caution.Pediatric research · 2026Article
- Therapeutic hypothermia and in-hospital mortality in 35-week infants with encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Evidence versus equipoise in late preterm neonates with encephalopathy; to cool or not to cool, that is the question!Pediatric research · 2026Article
- Benefits and risks of therapeutic hypothermia for hypoxic-ischemic encephalopathy in late preterm infants.Pediatric research · 2026Review
- Peculiarity of preterm neonates at 33-35 weeks gestational age with mild-to-severe hypoxic-ischaemic encephalopathy: a single-centre experience.European journal of pediatrics · 2026Article
- Translational Potential of Stem Cell-based Therapies in the Treatment of Neonatal Hypoxic-ischemic Brain Injury.Stem cell reviews and reports · 2025Review
- Brain Injury Patterns and Short-TermOutcomes in Late Preterm Infants Treated with Hypothermia for Hypoxic Ischemic Encephalopathy.Children (Basel, Switzerland) · 2025Article
- The shifting landscape of the preterm brain.Neuron · 2025Review
- Therapeutic hypothermia in preterm infants under 36 weeks: Case series on outcomes and brain MRI findings.European journal of pediatrics · 2025Article
- β-estradiol alleviates hypoxic-ischemic brain damage in neonatal rats through the GPER1-mediated AKT/NF-κB signaling pathway.Archives of medical science : AMS · 2025Article
- Effect of Early Inhibition of Toll-Like Receptor 4 on Hippocampal Plasticity in a Neonatal Rat Model of Hypoxic-Ischemic Brain Damage.Molecular neurobiology · 2025Article
- Hypothermia for Hypoxic-ischemic Encephalopathy: Second-generation Trials to Address Gaps in Knowledge.Clinics in perinatology · 2024Review
- Therapeutic hypothermia for preterm infants 34-35 weeks gestational age with neonatal encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Neuroprotective therapies in the NICU in preterm infants: present and future (Neonatal Neurocritical Care Series).Pediatric research · 2024Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo evaluate the safety and short-term outcomes of preterm neonates born at 34-35 weeks gestation with hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia. STUDY
designMedical records of preterm neonates born at 34-35 weeks gestational age with HIE treated with therapeutic hypothermia were retrospectively reviewed. Short-term safety outcomes and the presence, severity (mild, moderate, severe), and patterns of brain injury on magnetic resonance imaging were reviewed using a standard scoring system, and compared with a cohort of term neonates with HIE treated with therapeutic hypothermia.
resultsThirty-one preterm and 32 term neonates were identified. Therapeutic hypothermia-associated complications were seen in 90% of preterm infants and 81.3% of term infants (P = .30). In the preterm infants, hyperglycemia (58.1% vs31.3%, P = .03) and rewarming before completion of therapeutic hypothermia (19.4% vs 0.0%, P = .009) were more likely compared with term infants. All deaths occurred in the preterm group (12.9% vs 0%, P = .04). Neuroimaging showed the presence of injury in 80.6% of preterm infants and 59.4% of term infants (P = .07), with no differences in injury severity. Injury to the white matter was more prevalent in preterm infants compared with term infants (66.7% vs 25.0%, P = .001).
conclusionsTherapeutic hypothermia in infants born at 34-35 weeks gestational age appears feasible. Risks of mortality and side effects warrant caution with use of therapeutic hypothermia in preterm infants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.