Evidence map›Paper›PMID 27979044›Full record

ArticleAmerican heart journal2017

Serum brain-derived neurotrophic factor and risk of atrial fibrillation.

Faisal Rahman, Jayandra J Himali, Xiaoyan Yin, Alexa S Beiser, Patrick T Ellinor, Steven A Lubitz, Ramachandran S Vasan, Jared W Magnani, David D McManus, Sudha Seshadri and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American heart journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Faisal RahmanDepartment of Medicine, Boston University Medical Center, Boston, MA, USA.
Jayandra J HimaliNational Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Xiaoyan YinNational Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Alexa S BeiserNational Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Patrick T EllinorCardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, USA.
Steven A LubitzCardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, USA.
Ramachandran S VasanNational Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Jared W MagnaniDepartment of Medicine, Division of Cardiology, UPMC Heart & Vascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.
David D McManusNational Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Sudha Seshadri *National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Emelia J Benjamin *National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Framingham Heart Study · USBoston University · USMassachusetts General Hospital · USBoston Medical Center · USNational Heart Lung and Blood Institute · USUniversity of Pittsburgh · US

Funding

UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
Research Training and Education Core (Core D) P50HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2013 to 2017
$20.1M
AFGen Consortium: Atrial Fibrillation Genomics to Functional AnalysesR01HL128914 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2015 to 2018
$3.1M
Atrial Fibrillation: Bridging genetic discovery and clinical associationsK23HL114724 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LUBITZ, STEVEN A · 2013 to 2017
$893k
Doris Duke Charitable Foundation 2014105Doris Duke Charitable Foundation 2015084NHLBI NIH HHS K23 HL114724NHLBI NIH HHS P50 HL120163NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL128914NIA NIH HHS P30 AG010129NINDS NIH HHS R01 NS017950
6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) is expressed by endothelial cells and can affect cardiovascular function. We examined if serum BDNF was associated with risk of incident atrial fibrillation (AF) in the Framingham Heart Study.

methodsWe studied individuals without an AF diagnosis at baseline from the Framingham original and offspring cohorts. We used age- and sex-adjusted, and multivariable-adjusted Cox proportional hazards regression models to examine the association of serum BDNF concentrations with 10-year risk of incident AF.

resultsWe studied 3,457 participants (mean age 65±11years, 58% women). During follow-up, 395 participants developed AF. In unadjusted analysis, higher mean serum BDNF concentration was associated with lower incidence of AF (hazard ratio 0.89 per SD, 95% CI 0.80-0.99). In multivariable-adjusted analyses, serum BDNF concentration was not significantly associated with incident AF (hazard ratio 0.98 per SD, 95% CI 0.88-1.09). Compared with the lowest quartile, BDNF levels in the other quartiles were not associated with risk of AF in multivariable-adjusted analyses. No interactions between sex or age with serum BDNF concentrations and risk of AF were found.

conclusionsIn our prospective, community-based sample, we did not find a statistically significant association of serum BDNF levels with risk of incident AF.

Indexed as

AgedAtrial FibrillationBiomarkersBrain-Derived Neurotrophic FactorFemaleHumansIncidenceMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk FactorsBDNF protein, humanBiomarkersBrain-Derived Neurotrophic Factor

Identifiers

PMID27979044
PMCPMC5166602
OpenAlexW2539441407

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.