Evidence map›Paper›PMID 27979038›Full record

Trial reportAmerican heart journal2017

Baseline assessment and comparison of arterial anatomy, hyperemic flow, and skeletal muscle perfusion in peripheral artery disease: The Cardiovascular Cell Therapy Research Network "Patients with Intermittent Claudication Injected with ALDH Bright Cells" (CCTRN PACE) study.

Bharath Ambale Venkatesh, Victor Nauffal, Chikara Noda, Tomoki Fujii, Phillip C Yang, Judy Bettencourt, Erin P Ricketts, Michael Murphy, Nicholas J Leeper, Lem Moyé and 7 more

Open access · greenAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American heart journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 1 country.

Bharath Ambale VenkateshJohns Hopkins University, Baltimore, MD.
Victor NauffalJohns Hopkins University, Baltimore, MD.
Chikara NodaJohns Hopkins University, Baltimore, MD.
Tomoki FujiiJohns Hopkins University, Baltimore, MD.
Phillip C YangStanford University School of Medicine, Stanford, CA.
Judy BettencourtUniversity of Texas Houston Health Science Center, School of Public Health, Houston, TX.
Erin P RickettsJohns Hopkins University, Baltimore, MD.
Michael MurphyIndiana University School of Medicine, Bloomington, IN.
Nicholas J LeeperStanford University School of Medicine, Stanford, CA.
Lem MoyéUniversity of Texas Houston Health Science Center, School of Public Health, Houston, TX. Electronic address: lemmoye@msn.com.
Ray F EbertNIH, National Heart, Lung, and Blood Institute, Bethesda, MD.
Raja MuthupillaiTexas Heart Institute, Houston, TX.
David A BluemkeNIH, National Heart, Lung, and Blood Institute, Bethesda, MD.
Emerson C PerinTexas Heart Institute, Houston, TX.
Alan T HirschUniversity of Minnesota Medical School, Minneapolis, MN.
João A C LimaJohns Hopkins University, Baltimore, MD.
Cardiovascular Cell Therapy Research Network (CCTRN)
Johns Hopkins University · USNational Heart Lung and Blood Institute · USStanford University · USThe University of Texas Health Science Center at Houston · USIndiana University Bloomington · USUniversity of Minnesota Medical Center · US

Funding

Data Coordinating Center For The Cardiovascular Cell Therapy Research NetworkUM1HL087318 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DAVIS, BARRY R · 2012 to 2018
$29.8M
MN Regional Cardiovascular Cell Therapy Clinical Res. Network: From AMI to PADUM1HL087394 · NHLBI · UNIVERSITY OF MINNESOTA · PI HENRY, TIMOTHY D · 2012 to 2018
$5.1M
Molecular Biomedical Imaging Laboratory (NIBIB)ZIAEB000072 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI BLUEMKE, DAVID · 2010 to 2017
$5.0M
Cardiovascular Cell Therapy Research NetworkUM1HL087365 · NHLBI · TEXAS HEART INSTITUTE · PI PERIN, EMERSON CARVALHO, WILLERSON, JAMES T. · 2012 to 2018
$4.8M
Cell Characterization and Imaging for Regenerative Therapies in Ischemic DiseasesUM1HL113456 · NHLBI · STANFORD UNIVERSITY · PI YANG, PHILLIP CHUNG-MING · 2012 to 2018
$3.3M
MN Cardiovascular Cell Therapy Clinical Research Network: From AMI to CHFU01HL087394 · NHLBI · UNIVERSITY OF MINNESOTA · PI HENRY, TIMOTHY D · 2007 to 2011
$1.9M
The paradoxical role of CDKN2B in blood vessel sprouting and maturationR01HL125224 · NHLBI · STANFORD UNIVERSITY · PI LEEPER, NICHOLAS JAMES · 2015 to 2018
$1.9M
Patient Oriented Research in Cardiovascular RegenerationK24HL130553 · NHLBI · STANFORD UNIVERSITY · PI YANG, PHILLIP CHUNG-MING · 2016 to 2020
$584k
NHLBI NIH HHS K24 HL130553NHLBI NIH HHS R01 HL125224NHLBI NIH HHS U01 HL087394NHLBI NIH HHS UM1 HL087318NHLBI NIH HHS UM1 HL087365NHLBI NIH HHS UM1 HL087394NHLBI NIH HHS UM1 HL113456
6 · The paper itself

Abstract

backgroundPeripheral artery disease (PAD) is important to public health as a major contributor to cardiovascular morbidity and mortality. Recent developments in magnetic resonance imaging (MRI) techniques permit improved assessment of PAD anatomy and physiology, and may serve as surrogate end points after proangiogenic therapies.

methodsThe PACE study is a randomized, double-blind, placebo-controlled clinical trial designed to assess the physiologic impact and potential clinical efficacy of autologous bone marrow-derived ALDH

resultsThe interreader and intrareader and test-retest results demonstrated good-to-excellent reproducibility (interclass correlation coefficient range 0.61-0.98) for all magnetic resonance measures. The PAD participants (n=82) had lower capillary perfusion measured by calf muscle plasma volume (3.8% vs 5.6%) and peak hyperemic popliteal flow (4.1 vs 13.5mL/s) as compared with the healthy participants (n=16), with a significant level of collateralization.

conclusionsReproducibility of the MRI primary end points in PACE was very good to excellent. The PAD participants exhibited decreased calf muscle capillary perfusion as well as arterial flow reserve when compared with healthy participants. The MRI tools used in PACE may advance PAD science by enabling accurate measurement of PAD microvascular anatomy and perfusion before and after stem cell or other PAD therapies.

Indexed as

Hematopoietic Stem Cell TransplantationAutograftsDouble-Blind MethodFemaleHumansInjections, IntramuscularIntermittent ClaudicationLegMagnetic Resonance AngiographyMagnetic Resonance ImagingMaleMuscle, SkeletalPeripheral Arterial DiseaseRegional Blood Flow

Identifiers

PMID27979038
PMCPMC5172389
OpenAlexW2529845453

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.