Evidence map›Paper›PMID 27978855›Full record

ArticleAlzheimer's research & therapy2016

A digital enzyme-linked immunosorbent assay for ultrasensitive measurement of amyloid-β 1-42 peptide in human plasma with utility for studies of Alzheimer's disease therapeutics.

Linan Song, D Richard Lachno, David Hanlon, Adam Shepro, Andreas Jeromin, Dipika Gemani, Jayne A Talbot, Margaret M Racke, Jeffrey L Dage, Robert A Dean

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's research & therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. ADNI Biomarker Core: A review of progress since 2004 and future challenges.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. The Diagnostic Potential of Amyloidogenic Proteins.International journal of molecular sciences · 2021
    Review
  12. A β-AmyloidJournal of biomedical physics & engineering · 2021
    Article
  13. Article
  14. Article
  15. Label-Free Optical Resonator-Based Biosensors.Sensors (Basel, Switzerland) · 2020
    Review
  16. Article
  17. Review
  18. Au/NiFeNanoscale advances · 2020
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Linan SongQuanterix Corporation, Lexington, MA, USA.ORCID 0000-0002-3057-5345
D Richard LachnoEli Lilly and Company, Windlesham, UK. drlachno@lilly.com.
David HanlonQuanterix Corporation, Lexington, MA, USA. dhanlon@quanterix.com.
Adam SheproQuanterix Corporation, Lexington, MA, USA.
Andreas JerominQuanterix Corporation, Lexington, MA, USA.
Dipika GemaniQuanterix Corporation, Lexington, MA, USA.
Jayne A TalbotLilly Research Laboratories, Indianapolis, IN, USA.
Margaret M RackeLilly Research Laboratories, Indianapolis, IN, USA.
Jeffrey L DageLilly Research Laboratories, Indianapolis, IN, USA.
Robert A DeanLilly Research Laboratories, Indianapolis, IN, USA.
Eli Lilly (United States) · USQuanterix (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmyloid-β 1-42 peptide (Aβ

methodsA sensitive digital ELISA for measurement of Aβ

resultsThe prototype assay measured Aβ

conclusionsThis digital ELISA has potential utility in clinical applications for quantification of Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesEnzyme-Linked Immunosorbent AssayHumansPeptide FragmentsSensitivity and SpecificityAmyloid beta-Peptidesamyloid beta-protein (1-42)Peptide FragmentsAlzheimer’s diseaseAβ1–42Digital ELISAPlasmaTherapeuticUltrasensitive

Identifiers

PMID27978855
PMCPMC5160015
OpenAlexW2562595262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.