ArticleCancer imaging : the official publication of the International Cancer Imaging Society2016
CT-perfusion measurements in pancreatic carcinoma with different kinetic models: Is there a chance for tumour grading based on functional parameters?
Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Quantitative CT perfusion imaging in patients with pancreatic cancer: a systematic review.Abdominal radiology (New York) · 2022Pooled it
- Role of Dynamic Perfusion CT in Pancreatic Adenocarcinoma.The Indian journal of radiology & imaging · 2026Article
- Multi-drug pharmacotyping improves therapy prediction in pancreatic cancer organoids.Cancer cell international · 2025Article
- Innovative imaging approaches for neuroendocrine tumor characterization: Combined dual energy CT and perfusion protocol implementation.Radiology case reports · 2024Article
- Automated Quantitative Analysis of CT Perfusion to Classify Vascular Phenotypes of Pancreatic Ductal Adenocarcinoma.Cancers · 2024Article
- Pancreatic CT perfusion: quantitative meta-analysis of disease discrimination, protocol development, and effect of CT parameters.Insights into imaging · 2023Article
- Assessment of tissue perfusion of pancreatic cancer as potential imaging biomarker by means of Intravoxel incoherent motion MRI and CT perfusion: correlation with histological microvessel density as ground truth.Cancer imaging : the official publication of the International Cancer Imaging Society · 2021Article
- Dynamic perfusion CT - A promising tool to diagnose pancreatic ductal adenocarcinoma.Open medicine (Warsaw, Poland) · 2021Article
- Evaluation of the effect of image noise on CT perfusion measurements using digital perfusion phantoms.European radiology · 2019Article
- The feasibility of low-concentration contrast and low tube voltage in computed tomography perfusion imaging: an animal study.Bioscience reports · 2018Article
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7 authors at 1 institution in 1 country.
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Abstract
backgroundTo evaluate the interchangeability of perfusion parameters obtained with help of models used for post-processing of perfusion-CT images in pancreatic adenocarcinoma and to determine the mean values and ranges of perfusion in different tumour gradings.
methodsPerfusion-CT imaging was performed prospectively in 48 consecutive patients with pancreatic adenocarcinoma. In 42 patients biopsy-proven tumor grading was available (4 × G1/24 × G2/14 × G3/6× unknown). Images were post-processed using a model based on the maximum-slope (MS) approach (blood flow-BFMS) + Patlak analysis (P) (blood volume [BVP] and permeability [k-transP]), as well as a model with deconvolution-based (D) analysis (BFD, BVD and k-transD). 50 mL contrast agent were applied with a delay time of 7 s. Perfusion parameters were compared using intraclass correlation coefficient (ICC), the Wilcoxon matched-pairs test and Bland-Altman plots.
resultsForty eight VOIs of tumours were outlined and analysed. Moderate to good ICC values were found for the perfusion parameters (ICC = 0.62-0.75). Wilcoxon matched-pairs revealed significantly lower values (P < .001 and 0.008), for the BF and BV values obtained using the maximum-slope approach + Patlak analysis compared to deconvolution based analysis. For k-trans measurement, deconvolution revealed significantly lower values (P < 0.001). Different histologic subgroups (G1-G3) did not show significantly different functional parameters.
conclusionThere were significant differences in the perfusion parameters obtained using the different calculation methods, and therefore these parameters are not directly interchangeable. However, the magnitude of pairs of parametric values is in constant relation to each other enabling the use of any of these methods. VPCT parameters did not allow for histologic classification.
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