ArticleBMC neurology2016
Critical illness polyneuropathy (CIP) in neurological early rehabilitation: clinical and neurophysiological features.
Article in BMC neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Challenges in managing prolonged intensive care unit stay for Guillain-Barré syndrome-acute motor axonal neuropathy variant.SAGE open medical case reports · 2026Article
- Differences in functional outcome of COVID-19 and non-COVID-19 patients with critical illness polyneuropathy/ myopathy: a multicenter cohort study.Journal of neurology · 2025Observational
- Incidence and risk factors of peripheral nerve injuries 3 months after ICU discharge: a retrospective study comparing COVID-19 and non-COVID-19 critically ill survivors.Journal of anesthesia, analgesia and critical care · 2024Article
- [The Respiratory Therapist in Neurology An Evolving Specialization in Germany].Fortschritte der Neurologie-Psychiatrie · 2023Article
- Recovery and long term functional outcome in people with critical illness polyneuropathy and myopathy: a scoping review.BMC neurology · 2022Article
- Pathophysiology and management of critical illness polyneuropathy and myopathy.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Stiff-person syndrome coexisting with critical illness polyneuropathy: A case report.Medicine · 2020Article
- [Weaning in neurological and neurosurgical early rehabilitation-Results from the "WennFrüh" study of the German Society for Neurorehabilitation].Der Nervenarzt · 2020Article
- [Sepsis impairs aggregation of nicotinic acetylcholine receptors on murine skeletal muscle cell membranes by inhibiting AKT/GSK3β phosphorylation].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCritical illness polyneuropathy (CIP) is a complex disease affecting 30-70% of critically ill patients.
methodsClinical (Barthel index, length of stay (LOS), morbidity, duration of mechanical ventilation, routine lab results) and neurophysiological (neurography) data of 191 patients admitted to neurological early rehabilitation and diagnosed with CIP have been analyzed retrospectively.
resultsCIP diagnosis was correct in 159 cases (83%). In this study, systemic inflammation, sepsis, systemic inflammatory response syndrome (SIRS), multiple organic failure (MOF), chronic renal failure, liver dysfunction, mechanical ventilation, diabetes, dyslipidemia and impaired ion homeostasis (hypocalcaemia, hypokalemia) were associated with CIP. Neurography, in particular of the peroneal, sural, tibial and median nerves, helped to identify CIP patients. Compound muscle action potential amplitude (r = -0.324, p < 0.05), as well as sensory (r = -0.389, p < 0.05) and motor conduction velocity (r = -0.347, p < 0.05) of the median nerve correlated with LOS in neurological early rehabilitation but not with outcome measures.
conclusionsIn most cases, diagnosis of CIP among neurological early rehabilitation patients seems to be correct. Neurography may help to verify the diagnosis and to learn more about CIP pathophysiology, but it does not allow outcome prediction. Further studies on CIP are strongly encouraged.
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