ArticlePLoS pathogens2016
Large-Scale Phylogenomic Analysis Reveals the Complex Evolutionary History of Rabies Virus in Multiple Carnivore Hosts.
Article in PLoS pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.
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Who cites it
113 citing papers in PubMed, 230 citations in OpenAlex.
- Molecular Genetic Analysis of the Rabies Virus in Wild and Domestic Animals of Kazakhstan and the Development of a Diagnostic System.Pathogens (Basel, Switzerland) · 2026Article
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- High sensitivity of the Bionote Anigen Rapid Rabies Antigen Test in detection of diverse rabies virus variants suggests utility for global rabies control.Journal of clinical microbiology · 2026Article
- First complete genomic sequencing of recent canine rabies viruses in Sierra Leone suggests cross-border transmission of Africa 2H subclade.Virologica Sinica · 2026Article
- Fatal encephalomyelitis outbreak among dairy cows caused by rabies virus phylogroup-1 with co-occurrence of Chlamydia abortus.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Rabies virus nucleo- and glycoprotein coding sequences from dogs in Thailand (2022-2024).Microbiology resource announcements · 2026Article
- Origin, distribution and incidence of human rabies in Côte d'Ivoire from 2013 to 2023.Journal of virus eradication · 2026Article
- Rabies and Pinnipeds Reviewed: Premonitions, Perturbations, and Projections?Veterinary sciences · 2026Review
- Comprehensive genomic analysis of rabies virus in India reveals distinct lineages and evolutionary stability.Virus genes · 2026Article
- Differences in codon usage between host-species-specific rabies virus clades are driven by non-GC3 nucleotide composition.Virus evolution · 2026Article
- Spatiotemporal Metabolome analysis reveals a metabolic network during development of the waxy sorghum landrace 'Hongyingzi'.Frontiers in plant science · 2026Article
- Reconstructing the molecular epidemiology of rabies in Switzerland from outbreak to elimination (1967-97).Virus evolution · 2026Article
- Synthesizing selection mosaic theory and host-pathogen theory to explain large-scale pathogen coexistence.Nature communications · 2025Article
- First detection of rabies virus in encephalitic goats (Capra hircus) from Sarawak, Malaysian Borneo: a case study report.BMC veterinary research · 2025Article
- The Challenge of Lyssavirus Infections in Domestic and Other Animals: A Mix of Virological Confusion, Consternation, Chagrin, and Curiosity.Pathogens (Basel, Switzerland) · 2025Review
- A logistic regression model to predict the next rabies virus host-shift event.Scientific reports · 2025Article
- Genomic characterization of a dog-mediated rabies outbreak in El Pedregal, Arequipa, Peru.PLoS neglected tropical diseases · 2025Article
- Spatial Landscape Structure Influences Cross-Species Transmission in a Rabies-like Virus Model.Microorganisms · 2025Article
- Phylogeography Analysis Reveals Rabies Epidemiology, Evolution, and Transmission in the Philippines.Molecular biology and evolution · 2025Article
- Typing Arctic and Africa-2 clades of rabies virus using clade-defining single nucleotide polymorphisms.Archives of microbiology · 2025Article
53 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The natural evolution of rabies virus (RABV) provides a potent example of multiple host shifts and an important opportunity to determine the mechanisms that underpin viral emergence. Using 321 genome sequences spanning an unprecedented diversity of RABV, we compared evolutionary rates and selection pressures in viruses sampled from multiple primary host shifts that occurred on various continents. Two major phylogenetic groups, bat-related RABV and dog-related RABV, experiencing markedly different evolutionary dynamics were identified. While no correlation between time and genetic divergence was found in bat-related RABV, the evolution of dog-related RABV followed a generally clock-like structure, although with a relatively low evolutionary rate. Subsequent molecular clock dating indicated that dog-related RABV likely underwent a rapid global spread following the intensification of intercontinental trade starting in the 15th century. Strikingly, although dog RABV has jumped to various wildlife species from the order Carnivora, we found no clear evidence that these host-jumping events involved adaptive evolution, with RABV instead characterized by strong purifying selection, suggesting that ecological processes also play an important role in shaping patterns of emergence. However, specific amino acid changes were associated with the parallel emergence of RABV in ferret-badgers in Asia, and some host shifts were associated with increases in evolutionary rate, particularly in the ferret-badger and mongoose, implying that changes in host species can have important impacts on evolutionary dynamics.
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