ArticleMedicine2016
Serum apolipoprotein E concentration and polymorphism influence serum lipid levels in Chinese Shandong Han population.
Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Effect of High-Salt Diet on Memory and Behavior in Mice Expressing Human Apolipoprotein Epsilon-4 (APOE4) Allele.NeuroSci · 2026Article
- Article
- Association ofSaudi journal of biological sciences · 2023Article
- Article
- Association between clinical symptoms and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia.Annals of general psychiatry · 2021Article
- The effects of genetic polymorphisms of APOE on circulating lipid levels in middle-aged and elderly chinese Fujian Han population: toward age- and sex-personalized management.Lipids in health and disease · 2021Article
- Article
- Single Nucleotide Polymorphisms inFrontiers in genetics · 2021Article
- Alcohol Drinking, Apolipoprotein Polymorphisms and the Risk of Cardiovascular Diseases.Current neurovascular research · 2021Review
- Apolipoprotein E Gene Polymorphism and Coronary Artery Disease Risk Among Patients in Northwest China.Pharmacogenomics and personalized medicine · 2021Article
- Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver.Nature communications · 2020Article
- The value of apolipoprotein E in distinguishing benign and malignant unilateral pleural effusions.Medicine · 2020Article
- Association of Apolipoprotein E Polymorphisms with White Matter Lesions and Brain Atrophy.Psychiatry investigation · 2020Article
- Apolipoprotein E gene polymorphism and renal function are associated with apolipoprotein E concentration in patients with chronic kidney disease.Lipids in health and disease · 2019Article
- Serum lipid and lipoprotein levels of middle-aged and elderly Chinese men and women in Shandong Province.Lipids in health and disease · 2019Article
- Depression was associated with apolipoprotein E ε4 allele polymorphism: A meta-analysis.Iranian journal of basic medical sciences · 2019Review
- Polymorphism and plasma levels of apolipoprotein E and the risk of aneurysmal subarachnoid hemorrhage in a Chinese population: a case-control study.Lipids in health and disease · 2018Article
- Association of APOE Gene Polymorphisms with Cerebral Infarction in the Chinese Population.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apolipoprotein E (ApoE), which has been shown to influence serum lipid parameters, can bind to multiple types of lipids and plays an important role in the metabolism and homeostasis of lipids and lipoproteins. A previous study showed that ApoE concentration significantly affects serum lipid levels independently of ApoE polymorphism. The serum lipid levels were also closely correlated with dietary habits, and Shandong cuisine is famous for its high salt and oil contents, which widely differ among the different areas in China. Therefore, studying the effect of ApoE polymorphism on ApoE concentration and serum lipid levels in Shandong province is very important.A total of 815 subjects including 285 men and 530 women were randomly selected and studied from Jinan, Shandong province. In order to evaluate the association of ApoE polymorphism and serum level on lipid profiles, the ApoE genotypes, as well as levels of fasting serum ApoE and other lipid parameters, were detected in all subjects.The frequency of the ApoE E3 allele was highest (83.1%), while those of E2 and E4 were 9.4% and 7.5%, respectively, which are similar to those in other Asian populations. ApoE2 allele carriers showed significantly increased ApoE levels but lower levels of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and Apolipoprotein B (ApoB).We found that ApoE level is influenced by ApoE polymorphism in a gene-dependent manner. The ApoE polymorphism showed different influences on serum lipid parameters with increasing age and body mass index (BMI) in our Shandong Han population.
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