Observational studyMedicine2016
Injury of the lower ascending reticular activating system in patients with pontine hemorrhage: Diffusion tensor imaging study.
Observational study in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.
- Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness.Frontiers in neurology · 2025Pooled it
- Clinical application of diffusion tensor imaging and fiber tractography in the management of brainstem cavernous malformations: a systematic review.Neurosurgical review · 2022Pooled it
- Global White Matter Damage in Focal Brainstem Injury Patients With Disorders of Consciousness: A Diffusion Tensor Tractography Study.European journal of neurology · 2026Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many studies have reported about injury of the ascending reticular activating system (ARAS) in patients with various brain pathologies, using diffusion tensor tractography (DTT); however, little is known about injury of the ARAS in patients with pontine hemorrhage. In this study, using DTT, we attempted to investigate injury of the lower ventral and dorsal ARAS in patients with pontine hemorrhage. Twenty-three consecutive patients with pontine hemorrhage and 14 control subjects were recruited into this study. The patients were classified into 2 subgroups on the basis of the preservation of arousal: subgroup A (14 patients)-intact arousal, subgroup B (9 patients)-impaired arousal. The lower ventral and dorsal ARAS between the pontine reticular formation with hypothalamus and thalamic intralaminar nucleus were reconstructed. Fractional anisotropy (FA), mean diffusivity (MD), and tract volume (TV) values were measured. The TVs of the lower ventral and dorsal ARAS were significantly lower in subgroup B than in the subgroup A and control group (P < 0.05). In terms of FA value, the lower dorsal ARAS were significantly lower in subgroup A and subgroup B than in the control group (P < 0.05). In conclusion, injury of the lower ventral and dorsal ARAS was demonstrated in patients with impaired arousal following pontine hemorrhage. We believe that analysis of the ARAS using DTT would be helpful in evaluation of patients with impaired consciousness after pontine hemorrhage.
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Registered trials
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