Evidence map›Paper›PMID 27977518›Full record

Trial reportJournal of neurologic physical therapy : JNPT2017

Effects of 2 Years of Exercise on Gait Impairment in People With Parkinson Disease: The PRET-PD Randomized Trial.

Miriam R Rafferty, Janey Prodoehl, Julie A Robichaud, Fabian J David, Cynthia Poon, Lisa C Goelz, David E Vaillancourt, Wendy M Kohrt, Cynthia L Comella, Daniel M Corcos

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurologic physical therapy : JNPT, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 6 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 6 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Pooled it
  6. Pooled it
  7. Neuroprotection in Parkinson Disease.Neurology and therapy · 2025
    Review
  8. Article
  9. Article
  10. Frontiers in sports and active living · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. The role of exercise in Parkinson's Disease.Neurosciences (Riyadh, Saudi Arabia) · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Miriam R RaffertyCenter for Education in Health Sciences (M.R.R.) and Physical Therapy and Human Movement Science (F.J.D., C.P., D.M.C.), Northwestern University, Chicago, Illinois; Physical Therapy Program, Midwestern University, Downer's Grove, Illinois (J.P.); Department of Rehabilitation Services, University of Illinois Hospital and Health Science System, Chicago (J.A.R.); Department of Kinesiology and Nutrition, University of Illinois at Chicago (L.C.G.); Department of Applied Physiology and Kinesiology, University of Florida, Gainesville (D.E.V.); Division of Geriatric Medicine, University of Colorado School of Medicine, Aurora (W.M.K.); and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois (C.L.C.).
Janey Prodoehl
Julie A Robichaud
Fabian J David
Cynthia Poon
Lisa C Goelz
David E Vaillancourt
Wendy M Kohrt
Cynthia L Comella
Daniel M Corcos
United States Nuclear Regulatory Commission · US

Funding

Training in the Neuroscience of Mental HealthT32MH067631 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI RASENICK, MARK M. · 2004 to 2024
$4.8M
MOTOR DEFICITS--EXPERIMENTAL AND CLINICAL CORRELATESR01NS028127 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CORCOS, DANIEL M. · 1993 to 2011
$4.0M
NIMH NIH HHS T32 MH067631NINDS NIH HHS R01 NS028127
6 · The paper itself

Abstract

background and purposeThis study presents a secondary analysis from the Progressive Resistance Exercise Training in Parkinson Disease (PRET-PD) trial investigating the effects of progressive resistance exercise (PRE) and a Parkinson disease (PD)-specific multimodal exercise program, modified Fitness Counts (mFC), on spatial, temporal, and stability-related gait impairments in people with PD.

methodsForty-eight people with PD were randomized to participate in PRE or mFC 2 times a week for 24 months; 38 completed the study. Gait velocity, stride length, cadence, and double-support time were measured under 4 walking conditions (off-/on-medication, comfortable/fast speed). Ankle strength was also measured off- and on-medication. Twenty-four healthy controls provided comparison data at one time point.

resultsAt 24 months, there were no significant differences between exercise groups. Both groups improved fast gait velocity off-medication, cadence in all conditions, and plantarflexion strength off-/on-medication. Both groups with PD had more gait measures that approximated the healthy controls at 24 months than at baseline. Plantarflexion strength was significantly associated with gait velocity and stride length in people with PD at baseline and 24 months, but changes in strength were not associated with changes in gait. DISCUSSION AND

conclusionsTwenty-four months of PRE and mFC were associated with improved off-medication fast gait velocity and improved cadence in all conditions, which is important because temporal gait measures can be resistant to medications. Spatial and stability-related measures were resistant to long-term improvements, but did not decline over 24 months. Strength gains did not appear to transfer to gait.Video Abstract available for more insights from the authors (see Supplemental Digital Content 1, http://links.lww.com/JNPT/A161).

Indexed as

Exercise TherapyAgedGait Disorders, NeurologicHumansMiddle AgedParkinson DiseaseProspective StudiesResistance Training

Identifiers

PMID27977518
PMCPMC5161103
OpenAlexW2562181972

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.