Evidence map›Paper›PMID 27977335›Full record

ArticlePharmacogenomics2017

Fatty acid amide hydrolase-morphine interaction influences ventilatory response to hypercapnia and postoperative opioid outcomes in children.

Vidya Chidambaran, Valentina Pilipenko, Kristie Spruance, Raja Venkatasubramanian, Jing Niu, Tsuyoshi Fukuda, Tomoyuki Mizuno, Kejian Zhang, Kenneth Kaufman, Alexander A Vinks and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacogenomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Genes · 2023
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Vidya ChidambaranDepartment of Anesthesia, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA.
Valentina PilipenkoDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Kristie SpruanceDepartment of Anesthesia, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA.
Raja VenkatasubramanianDepartment of Anesthesia, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA.
Jing NiuDepartment of Anesthesia, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA.
Tsuyoshi FukudaDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA.
Tomoyuki MizunoDivision of Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Kejian ZhangDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Kenneth KaufmanCenter for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Alexander A VinksDivision of Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Lisa J MartinDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA.
Senthilkumar SadhasivamDepartment of Anesthesia, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA.

Funding

Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., TSEVAT, JOEL · 2012 to 2014
$9.9M
Morphine Pharmacogenomics to Predict Risk of Respiratory Depression in ChildrenK23HD082782 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI CHIDAMBARAN, VIDYA · 2014 to 2018
$655k
NCATS NIH HHS UL1 TR000077NICHD NIH HHS K23 HD082782
6 · The paper itself

Abstract

aimFatty acid amide hydrolase (FAAH) degrades anandamide, an endogenous cannabinoid. We hypothesized that FAAH variants will predict risk of morphine-related adverse outcomes due to opioid-endocannabinoid interactions. PATIENTS &

methodsIn 101 postsurgical adolescents receiving morphine analgesia, we prospectively studied ventilatory response to 5% CO

resultsWe found significant FAAH-morphine interaction for missense (rs324420) and several regulatory variants, with HCVR (p < 0.0001) and vomiting (p = 0.0339). HCVR was more depressed in patients who developed RD compared with those who did not (p = 0.0034), thus FAAH-HCVR association predicts risk of impending RD from morphine use.

conclusionFAAH genotypes predict risk for morphine-related adverse outcomes.

Indexed as

AdolescentAmidohydrolasesAnalgesics, OpioidChildCohort StudiesFatty Acid Amide HydrolasesFemaleHumansHypercapniaLinkage DisequilibriumMaleMorphinePolymorphism, Single NucleotidePostoperative ComplicationsProspective StudiesPulmonary VentilationAmidohydrolasesAnalgesics, OpioidFatty Acid Amide HydrolasesMorphineFAAHfatty acid amide hydrolasehypercapnic ventilatory responsemorphineopioid–cannabinoid interactionspostoperativerespiratory depression

Identifiers

PMID27977335
PMCPMC5558540

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.