ArticleAnnals of the American Thoracic Society2017
House Dust Endotoxin Levels Are Associated with Adult Asthma in a U.S. Farming Population.
Article in Annals of the American Thoracic Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07328516 (Natural History Study of Early Life Exposures in Agriculture), which is not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Natural History Study of Early Life Exposures in Agriculture (ELEA)
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Interaction between Genetic Risk Scores for reduced pulmonary function and smoking, asthma and endotoxin.Thorax · 2021Pooled it
- Association of indoor microbial aerosols with respiratory symptoms among under-five children: a systematic review and meta-analysis.Environmental health : a global access science source · 2021Pooled it
- Residential proximity to intensive animal agriculture associates with increased prevalence of antimicrobial resistance in homes.Journal of exposure science & environmental epidemiology · 2026Article
- Classroom microbiome signatures of pest management associate with reduced asthma symptoms.The Journal of allergy and clinical immunology · 2026Article
- Smoking drives an epigenetic memory of aberrant hematopoiesis.medRxiv : the preprint server for health sciences · 2026Article
- Indoor endotoxin and house dust mite concentrations in the canine homologue of human atopic dermatitis.One health (Amsterdam, Netherlands) · 2025Article
- Harnessing the Farm Effect: Microbial Products for the Treatment and Prevention of Asthma Throughout Life.Immunological reviews · 2025Review
- Respiratory Diseases Associated With Organic Dust Exposure.The journal of allergy and clinical immunology. In practice · 2024Review
- Article
- Environmental Interventions for Preventing Atopic Diseases.Current allergy and asthma reports · 2024Review
- Longitudinal dynamics of farmer and livestock nasal and faecal microbiomes and resistomes.Nature microbiology · 2024Article
- Occupational farm work activities influence workers' indoor home microbiome.Environmental research · 2024Article
- Metagenomics reveals novel microbial signatures of farm exposures in house dust.medRxiv : the preprint server for health sciences · 2023Article
- Metagenomics reveals novel microbial signatures of farm exposures in house dust.Frontiers in microbiology · 2023Article
- Early-life farm exposures and eczema among adults in the Agricultural Lung Health Study.The journal of allergy and clinical immunology. Global · 2022Article
- Influence of Rural Environmental Factors in Asthma.Immunology and allergy clinics of North America · 2022Review
- Associations between airborne crude oil chemicals and symptom-based asthma.Environment international · 2022Article
- Mice Expressing Cosegregating Single Nucleotide Polymorphisms (D298G and N397I) in TLR4 Have Enhanced Responses to House Dust Mite Allergen.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- A neutrophil/TGF-β axis limits the pathogenicity of allergen-specific CD4+ T cells.JCI insight · 2022Article
- TLR Signaling Pathway Gene Polymorphisms, Gene-Gene and Gene-Environment Interactions in Allergic Rhinitis.Journal of inflammation research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 7 institutions in 1 country.
Funding
Abstract
rationaleEndotoxin initiates a proinflammatory response from the innate immune system. Studies in children suggest that endotoxin exposure from house dust may be an important risk factor for asthma, but few studies have been conducted in adult populations.
objectivesTo investigate the association of house dust endotoxin levels with asthma and related phenotypes (wheeze, atopy, and pulmonary function) in a large U.S. farming population.
methodsDust was collected from the bedrooms (n = 2,485) of participants enrolled in a case-control study of current asthma (927 cases) nested within the Agricultural Health Study. Dust endotoxin was measured by Limulus amebocyte lysate assay. Outcomes were measured by questionnaire, spirometry, and blood draw. We evaluated associations using linear and logistic regression. MEASUREMENTS AND MAIN
resultsEndotoxin was significantly associated with current asthma (odds ratio [OR], 1.30; 95% confidence interval [CI], 1.14-1.47), and this relationship was modified by early-life farm exposure (born on a farm: OR, 1.18; 95% CI, 1.02-1.37; not born on a farm: OR, 1.67; 95% CI, 1.26-2.20; Interaction P = 0.05). Significant positive associations were seen with both atopic and nonatopic asthma. Endotoxin was not related to either atopy or wheeze. Higher endotoxin was related to lower FEV
conclusionsHouse dust endotoxin was associated with current atopic and nonatopic asthma in a U.S. farming population. The degree of the association with asthma depended on early-life farm exposures. Furthermore, endotoxin was associated with lower pulmonary function in patients with asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.