ArticleeLife2016
Spinal microcircuits comprising dI3 interneurons are necessary for motor functional recovery following spinal cord transection.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed.
- Roles of spinal V3 interneurons: Roles in controlling movement in healthy and injured conditions.Neural regeneration research · 2026Article
- Autogenic spinal excitatory circuit ensures skilled hand movements in primates.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Molecularly diverse glycinergic interneurons in the medial deep dorsal horn are interposed between primary sensory afferents and spinal Shox2 interneurons.Frontiers in neural circuits · 2026Article
- Biologically-constrained spiking neural network for neuromodulation in locomotor recovery after spinal cord injury.PLoS computational biology · 2026Article
- Activity of spinal RORβ neurons is related to functional improvements following combination treatment after complete SCI.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Grid-based transcutaneous spinal cord stimulation: probing neuromodulatory effect in spinal flexion reflex circuits.Journal of neural engineering · 2025Article
- Review
- Dual electrical stimulation at spinal-muscular interface reconstructs spinal sensorimotor circuits after spinal cord injury.Nature communications · 2024Article
- Distinguishing subtypes of spinal locomotor neurons to inform circuit function and dysfunction.Current opinion in neurobiology · 2023Review
- Neuroplasticity and regeneration after spinal cord injury.North American Spine Society journal · 2023Article
- Changes in synaptic inputs to dI3 INs and MNs after complete transection in adult mice.Frontiers in neural circuits · 2023Article
- Natural and targeted circuit reorganization after spinal cord injury.Nature neuroscience · 2022Review
- Neurotransmitter phenotype switching by spinal excitatory interneurons regulates locomotor recovery after spinal cord injury.Nature neuroscience · 2022Article
- Chemogenetic modulation of sensory afferents induces locomotor changes and plasticity after spinal cord injury.Frontiers in molecular neuroscience · 2022Article
- Spinal Cord Injury Alters Spinal Shox2 Interneurons by Enhancing Excitatory Synaptic Input and Serotonergic Modulation While Maintaining Intrinsic Properties in Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Restoring Sensorimotor Function Through Neuromodulation After Spinal Cord Injury: Progress and Remaining Challenges.Frontiers in neuroscience · 2021Review
- Epidural Electrical Stimulation: A Review of Plasticity Mechanisms That Are Hypothesized to Underlie Enhanced Recovery From Spinal Cord Injury With Stimulation.Frontiers in molecular neuroscience · 2020Article
- The recovery of standing and locomotion after spinal cord injury does not require task-specific training.eLife · 2019Article
- The rhythm section: An update on spinal interneurons setting the beat for mammalian locomotion.Current opinion in physiology · 2019Article
- Locomotor-related V3 interneurons initiate and coordinate muscles spasms after spinal cord injury.Journal of neurophysiology · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The spinal cord has the capacity to coordinate motor activities such as locomotion. Following spinal transection, functional activity can be regained, to a degree, following motor training. To identify microcircuits involved in this recovery, we studied a population of mouse spinal interneurons known to receive direct afferent inputs and project to intermediate and ventral regions of the spinal cord. We demonstrate that while dI3 interneurons are not necessary for normal locomotor activity, locomotor circuits rhythmically inhibit them and dI3 interneurons can activate these circuits. Removing dI3 interneurons from spinal microcircuits by eliminating their synaptic transmission left locomotion more or less unchanged, but abolished functional recovery, indicating that dI3 interneurons are a necessary cellular substrate for motor system plasticity following transection. We suggest that dI3 interneurons compare inputs from locomotor circuits with sensory afferent inputs to compute sensory prediction errors that then modify locomotor circuits to effect motor recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.