ArticleeLife2016
Stereotyped responses of
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Phase-Resolved Pupal Ecdysis Behavior and Requirement of Ecdysis-Triggering Hormone in Henosepilachna vigintioctomaculata.Archives of insect biochemistry and physiology · 2026Article
- Expression and RNAi characterization of neuropeptides underlying developmental regulation in the Colorado potato beetle.Frontiers in insect science · 2026Article
- Characterization of eclosion hormone receptor function reveals differential hormonal control of ecdysis during Drosophila development.PLoS genetics · 2025Article
- Characterization Eclosion Hormone Receptor function reveals differential hormonal control of ecdysis duringbioRxiv : the preprint server for biology · 2025Article
- Using insecticidal compounds to elucidate the potential role of neurotransmitters in Lepidoptera pupal ecdysis.Scientific reports · 2025Article
- Neuromodulation and the toolkit for behavioural evolution: can ecdysis shed light on an old problem?The FEBS journal · 2024Review
- System-wide mapping of peptide-GPCR interactions in C. elegans.Cell reports · 2023Article
- Review
- Extracting temporal relationships between weakly coupled peptidergic and motoneuronal signaling: Application to Drosophila ecdysis behavior.PLoS computational biology · 2021Article
- Neonicotinoids can cause arrested pupal ecdysis in Lepidoptera.Scientific reports · 2021Article
- Pupal behavior emerges from unstructured muscle activity in response to neuromodulation ineLife · 2021Article
- Article
- Regulation ofFrontiers in neuroscience · 2021Article
- The tanning hormone, bursicon, does not act directly on the epidermis to tan the Drosophila exoskeleton.BMC biology · 2020Article
- Two Splice Isoforms ofFrontiers in physiology · 2020Article
- Insect Behavior and Physiological Adaptation Mechanisms Under Starvation Stress.Frontiers in physiology · 2019Article
- Distinct Co-Modulation Rules of Synapses and Voltage-Gated Currents Coordinate Interactions of Multiple Neuromodulators.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Article
- Ecdysis Triggering Hormone Signaling (ETH/ETHR-A) Is Required for the Larva-Larva Ecdysis inFrontiers in physiology · 2017Article
- WEclMon - A simple and robust camera-based system to monitor Drosophila eclosion under optogenetic manipulation and natural conditions.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropeptides play a key role in the regulation of behaviors and physiological responses including alertness, social recognition, and hunger, yet, their mechanism of action is poorly understood. Here, we focus on the endocrine control ecdysis behavior, which is used by arthropods to shed their cuticle at the end of every molt. Ecdysis is triggered by ETH (Ecdysis triggering hormone), and we show that the response of peptidergic neurons that produce CCAP (crustacean cardioactive peptide), which are key targets of ETH and control the onset of ecdysis behavior, depends fundamentally on the actions of neuropeptides produced by other direct targets of ETH and released in a broad paracrine manner within the CNS; by autocrine influences from the CCAP neurons themselves; and by inhibitory actions mediated by GABA. Our findings provide insights into how this critical insect behavior is controlled and general principles for understanding how neuropeptides organize neuronal activity and behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.