Evidence map›Paper›PMID 27976725›Full record

ArticleScientific reports2016

Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice.

Si-Young Cho, Juewon Kim, Ji Hae Lee, Ji Hyun Sim, Dong-Hyun Cho, Il-Hong Bae, Hyunbok Lee, Min A Seol, Hyun Mu Shin, Tae-Joo Kim and 5 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 63 citations in OpenAlex.

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  15. An Examination ofEvidence-based complementary and alternative medicine : eCAM · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Si-Young ChoR&D Unit, AmorePacific Corporation, Gyeonggi-do 17074, Republic of Korea.
Juewon KimR&D Unit, AmorePacific Corporation, Gyeonggi-do 17074, Republic of Korea.
Ji Hae LeeR&D Unit, AmorePacific Corporation, Gyeonggi-do 17074, Republic of Korea.
Ji Hyun SimDepartment of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Dong-Hyun ChoR&D Unit, AmorePacific Corporation, Gyeonggi-do 17074, Republic of Korea.
Il-Hong BaeR&D Unit, AmorePacific Corporation, Gyeonggi-do 17074, Republic of Korea.
Hyunbok LeeR&D Unit, AmorePacific Corporation, Gyeonggi-do 17074, Republic of Korea.
Min A SeolDepartment of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Hyun Mu ShinDepartment of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Tae-Joo KimDepartment of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Dae-Yong KimCollege of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea.
Su-Hyung LeeCollege of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea.
Song Seok ShinR&D Unit, AmorePacific Corporation, Gyeonggi-do 17074, Republic of Korea.
Sin-Hyeog ImAcademy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS), Pohang, 37673, Republic of Korea.
Hang-Rae KimDepartment of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Amorepacific (South Korea) · KRSeoul National University · KRInstitute for Basic Science · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-associated immunological dysfunction (immunosenescence) is closely linked to perturbation of the gut microbiota. Here, we investigated whether syringaresinol (SYR), a polyphenolic lignan, modulates immune aging and the gut microbiota associated with this effect in middle-aged mice. Compared with age-matched control mice, SYR treatment delayed immunosenescence by enhancing the numbers of total CD3

Indexed as

AgingAnimalsArea Under CurveBifidobacteriumCD3 ComplexFemaleForkhead Box Protein O3FuransGastrointestinal MicrobiomeImmunosenescenceLactobacillusLignansMaleMice, Inbred C57BLMice, Inbred ICRRats, Sprague-DawleyCD3 ComplexForkhead Box Protein O3FuransLignanssyringaresinol

Identifiers

PMID27976725
PMCPMC5157019
OpenAlexW2561888265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.