ArticleScientific reports2016
Phospholipase D1 deficiency in mice causes nonalcoholic fatty liver disease via an autophagy defect.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Pooled it
- Article
- Phosphatidic acid is involved in regulation of autophagy in neurons in vitro and in vivo.Pflugers Archiv : European journal of physiology · 2024Article
- Chemical Composition and Insulin-Resistance Activity of Arginine-Loaded American Cranberry (Pharmaceutics · 2023Article
- Inhibition of phospholipase D1 ameliorates hepatocyte steatosis and non-alcoholic fatty liver disease.JHEP reports : innovation in hepatology · 2023Article
- Crystallographic mining of ASK1 regulators to unravel the intricate PPI interfaces for the discovery of small molecule.Computational and structural biotechnology journal · 2022Review
- Effect of exercise and diet intervention in NAFLD and NASH via GAB2 methylation.Cell & bioscience · 2021Article
- Emerging Roles of Impaired Autophagy in Fatty Liver Disease and Hepatocellular Carcinoma.International journal of hepatology · 2021Review
- Quercetin Improving Lipid Metabolism by Regulating Lipid Metabolism Pathway of Ileum Mucosa in Broilers.Oxidative medicine and cellular longevity · 2020Article
- The Role of Lipophagy in the Development and Treatment of Non-Alcoholic Fatty Liver Disease.Frontiers in endocrinology · 2020Review
- Simulated microgravity inhibits C2C12 myogenesis via phospholipase D2-induced Akt/FOXO1 regulation.Scientific reports · 2019Article
- Liver ASK1 protects from non-alcoholic fatty liver disease and fibrosis.EMBO molecular medicine · 2019Article
- The immunity-related GTPase M rs13361189 variant does not increase the risk for prevalent or incident steatosis; results from the Framingham Heart Study.Liver international : official journal of the International Association for the Study of the Liver · 2019Article
- IRGM Gene Variants Modify the Relationship Between Visceral Adipose Tissue and NAFLD in Patients With Crohn's Disease.Inflammatory bowel diseases · 2018Article
- Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease.Liver research (Beijing, China) · 2018Article
- Phospholipase D functional ablation has a protective effect in an Alzheimer's disease Caenorhabditis elegans model.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of triglycerides (TG) as lipid droplets in the liver. Although lipid-metabolizing enzymes are considered important in NAFLD, the involvement of phospholipase D1 (PLD1) has not yet been studied. Here, we show that the genetic ablation of PLD1 in mice induces NAFLD due to an autophagy defect. PLD1 expression was decreased in high-fat diet-induced NAFLD. Subsequently, PLD1 deficiency led to an increase in hepatic TGs and liver weight. Autophagic flux was blocked in Pld1
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.