ArticleNature communications2016
Ageing and brain white matter structure in 3,513 UK Biobank participants.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 294 papers, 4 of them syntheses that pooled it.
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Who cites it
294 citing papers in PubMed, 4 syntheses or guidelines pooled it.
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- Outcome measures for electric field modeling in tES and TMS: A systematic review and large-scale modeling study.NeuroImage · 2023Pooled it
- Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes.Nature genetics · 2023Pooled it
- Epigenome-wide association study of global cortical volumes in generation Scotland: Scottish family health study.Epigenetics · 2022Pooled it
- Differential cerebral white matter tract alterations in generalized anxiety disorder revealed by ultra-high-field 7 T diffusion-weighted imaging.Journal of affective disorders · 2026Article
- Multiomics Profiling Supports Cathepsin B as a Protective Factor in White Matter Hyperintensities and Cognition.Stroke · 2026Article
- Sex-related variability of white-matter tracts is robust to tractography methodology.Brain structure & function · 2026Article
- Divergent Multimodal Age-Association Profiles Across the Human Brain.Nature communications · 2026Article
- Effects of Physical Activity on Brain White Matter Integrity Are Region-, Dose-, and Age-Dependent: Findings From the Population-Based Rhineland Study.Aging cell · 2026Article
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- Streamline-Based Analysis: A novel framework for tractogram-driven streamline-wise statistical inference.Research square · 2026Article
- Neurodegeneration in Glaucoma: Microstructural Magnetic Resonance Imaging Evidence Within and Beyond the Visual Pathway.Investigative ophthalmology & visual science · 2026Article
- Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Structural MRI signature of late- versus adult-onset multiple sclerosis: a multiparametric study.Journal of neurology · 2026Article
- Aging and metabolism contribute separately to brain-body health.PLoS biology · 2026Article
- Periventricular gradient of normal-appearing white matter in normal aging and multiple neurological diseases.Journal of advanced research · 2026Article
- Regional heterogeneity in phenotypic and genetic associations between bone and brain in humans.Nature communications · 2026Article
- Peak width of skeletonized mean diffusivity reveals early and multifactorial white matter injury across sporadic and Down syndrome-associated Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Multiomics Profiling Supports Cathepsin B as a Protective Factor in Cerebral Small Vessel Disease.Research square · 2026Article
- Testing retrogenesis and physiological explanations for tract-wise white matter aging: links to developmental order, fiber calibre, and vascularization.GeroScience · 2026Article
234 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Quantifying the microstructural properties of the human brain's connections is necessary for understanding normal ageing and disease. Here we examine brain white matter magnetic resonance imaging (MRI) data in 3,513 generally healthy people aged 44.64-77.12 years from the UK Biobank. Using conventional water diffusion measures and newer, rarely studied indices from neurite orientation dispersion and density imaging, we document large age associations with white matter microstructure. Mean diffusivity is the most age-sensitive measure, with negative age associations strongest in the thalamic radiation and association fibres. White matter microstructure across brain tracts becomes increasingly correlated in older age. This may reflect an age-related aggregation of systemic detrimental effects. We report several other novel results, including age associations with hemisphere and sex, and comparative volumetric MRI analyses. Results from this unusually large, single-scanner sample provide one of the most extensive characterizations of age associations with major white matter tracts in the human brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.