Evidence map›Paper›PMID 27976680›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017

Genetic and Modeling Approaches Reveal Distinct Components of Impulsive Behavior.

Katherine M Nautiyal, Melanie M Wall, Shuai Wang, Valerie M Magalong, Susanne E Ahmari, Peter D Balsam, Carlos Blanco, René Hen

Open access · bronzeAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Serotonin dysfunction in ADHD.Journal of neurodevelopmental disorders · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Dopamine D2 receptors in nucleus accumbens cholinergic interneurons increase impulsive choice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Which came first: Cannabis use or deficits in impulse control?Progress in neuro-psychopharmacology & biological psychiatry · 2021
    Review
  16. Article
  17. Article
  18. Article
  19. Gambling disorder: an integrative review of animal and human studies.Annals of the New York Academy of Sciences · 2017
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Katherine M NautiyalDepartment of Psychiatry, Columbia University, New York, NY, USA.
Melanie M WallDepartment of Psychiatry, Columbia University, New York, NY, USA.
Shuai WangDepartment of Psychiatry, New York State Psychiatric Institute, New York, NY, USA.
Valerie M MagalongDepartment of Psychiatry, New York State Psychiatric Institute, New York, NY, USA.
Susanne E AhmariDepartment of Psychiatry, Translational Neuroscience Program; Center for Neuroscience Program and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA.
Peter D BalsamDepartment of Psychiatry, New York State Psychiatric Institute, New York, NY, USA.
Carlos BlancoDepartment of Psychiatry, New York State Psychiatric Institute, New York, NY, USA.
René HenDepartment of Psychiatry, Columbia University, New York, NY, USA.
New York Psychoanalytic Society and Institute · USNew York State Psychiatric InstituteTranslational Research in Oncology · FR

Funding

Timing & Associative LearningR01MH068073 · NIMH · BARNARD COLLEGE · PI BALSAM, PETER D. · 2003 to 2024
$8.0M
Dissecting serotonergic and dopaminergic contributions to the neural circuits underlying impulsive behavior.K99MH106731 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI NAUTIYAL, KATHERINE M · 2015 to 2016
$260k
NIMH NIH HHS K99 MH106731NIMH NIH HHS R01 MH068073
6 · The paper itself

Abstract

Impulsivity is an endophenotype found in many psychiatric disorders including substance use disorders, pathological gambling, and attention deficit hyperactivity disorder. Two behavioral features often considered in impulsive behavior are behavioral inhibition (impulsive action) and delayed gratification (impulsive choice). However, the extent to which these behavioral constructs represent distinct facets of behavior with discrete biological bases is unclear. To test the hypothesis that impulsive action and impulsive choice represent statistically independent behavioral constructs in mice, we collected behavioral measures of impulsivity in a single cohort of mice using well-validated operant behavioral paradigms. Mice with manipulation of serotonin 1B receptor (5-HT

Indexed as

Inhibition, PsychologicalAnimalsBehavior, AnimalDelay DiscountingDisease Models, AnimalFemaleImpulsive BehaviorMaleMice, TransgenicReceptor, Serotonin, 5-HT1BSex FactorsReceptor, Serotonin, 5-HT1B

Identifiers

PMID27976680
PMCPMC5437890
OpenAlexW2563469976

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.