ArticleScientific reports2016
Distinct effects of isoflurane on basal BOLD signals in tissue/vascular microstructures in rats.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Systematic Review: Anaesthetic Protocols and Management as Confounders in Rodent Blood Oxygen Level Dependent Functional Magnetic Resonance Imaging (BOLD fMRI)-Part A: Effects of Changes in Physiological Parameters.Frontiers in neuroscience · 2020Pooled it
- Transcranial focused ultrasound modulates spiking, LFP, and BOLD activity in the primate thalamus.Nature communications · 2026Article
- UltraFast Layer-Resolved Encoding (uFLARE) functional MRI deciphers bidirectional signaling from spontaneous activity.Nature communications · 2026Article
- Low β predicts motor output and cell degeneration in the A53T Parkinson's disease rat model.Brain : a journal of neurology · 2025Article
- Neuroimaging Model of Visceral Manipulation in an Awake Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Stroke-induced neuroplasticity in spiny mice in the absence of tissue regeneration.NPJ Regenerative medicine · 2024Article
- Extensive topographic remapping and functional sharpening in the adult rat visual pathway upon first visual experience.PLoS biology · 2023Article
- Translational Magnetic Resonance Imaging in Autism Spectrum Disorder From the Mouse Model to Human.Frontiers in neuroscience · 2022Review
- Article
- Low neuronal metabolism during isoflurane-induced burst suppression is related to synaptic inhibition while neurovascular coupling and mitochondrial function remain intact.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- CVN-AD Alzheimer's mice show premature reduction in neurovascular coupling in response to spreading depression and anoxia compared to aged controls.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Cranioplastic Surgery and Acclimation Training for Awake Mouse fMRI.Bio-protocol · 2021Article
- The Vasomotor Response to Dopamine Is Altered in the Rat Model of l-dopa-Induced Dyskinesia.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Systematic Review: Anesthetic Protocols and Management as Confounders in Rodent Blood Oxygen Level Dependent Functional Magnetic Resonance Imaging (BOLD fMRI)-Part B: Effects of Anesthetic Agents, Doses and Timing.Animals : an open access journal from MDPI · 2021Review
- Translationally Relevant Magnetic Resonance Imaging Markers in a Ferret Model of Closed Head Injury.Frontiers in neuroscience · 2021Article
- A longitudinal, multi-parametric functional MRI study to determine age-related changes in the rodent brain.NeuroImage · 2020Article
- Awake functional MRI detects neural circuit dysfunction in a mouse model of autism.Science advances · 2020Article
- Imaging Functional Recovery Following Ischemic Stroke: Clinical and Preclinical fMRI Studies.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020Review
- Purkinje cell number-correlated cerebrocerebellar circuit anomaly in the valproate model of autism.Scientific reports · 2019Article
- The impact of fasting on resting state brain networks in mice.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Isoflurane is a well-known volatile anesthetic. However, it remains equivocal whether its effects on BOLD signal differ depending on the types of intracranial structures, such as capillaries and large blood vessels. We compared dose-dependent effect of isoflurane on the basal BOLD signals in distinct cerebral structures (tissue structure or large vessels) using high resolution T2*-images at 9.4 T MRI system in rat somatosensory cortex. The local field potential (LFP) in the somatosensory cortex and mean arterial pressure (MAP) were also investigated. Isoflurane induced inverted U-shaped dose-dependent change in BOLD signal in large vessels and tissue regions: BOLD signal under 2.0% and 2.5% isoflurane significantly increased from the maintenance dose (1.5%) and that under 3.0% was similar to maintenance dose. Remarkably, BOLD signal increase in tissue regions under 2.5% was significantly smaller than that in large vessels. The MAP decreased monotonically due to the dose of isoflurane and the LFP was strongly suppressed under high dose (2.5% and 3.0%). These results indicate that isoflurane-induced alteration of MAP and neuronal activity affected BOLD signal and, especially, BOLD signal in the tissue regions was more affected by the neuronal activity.
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