Evidence map›Paper›PMID 27976374›Full record

Trial reportJournal of child psychology and psychiatry, and allied disciplines2017

Cognitive therapy as an early treatment for post-traumatic stress disorder in children and adolescents: a randomized controlled trial addressing preliminary efficacy and mechanisms of action.

Richard Meiser-Stedman, Patrick Smith, Anna McKinnon, Clare Dixon, David Trickey, Anke Ehlers, David M Clark, Adrian Boyle, Peter Watson, Ian Goodyer and 1 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of child psychology and psychiatry, and allied disciplines, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Richard Meiser-StedmanMedical Research Council Cognition and Brain Sciences Unit, Cambridge, UK.ORCID http://orcid.org/0000-0002-0262-623X
Patrick SmithInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Anna McKinnonMedical Research Council Cognition and Brain Sciences Unit, Cambridge, UK.
Clare DixonMedical Research Council Cognition and Brain Sciences Unit, Cambridge, UK.
David TrickeyAnna Freud Centre, London, UK.
Anke EhlersUniversity of Oxford, Oxford, UK.
David M ClarkUniversity of Oxford, Oxford, UK.
Adrian BoyleCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Peter WatsonMedical Research Council Cognition and Brain Sciences Unit, Cambridge, UK.
Ian GoodyerUniversity of Cambridge, Cambridge, UK.
Tim DalgleishMedical Research Council Cognition and Brain Sciences Unit, Cambridge, UK.

Funding

Medical Research Council MC_EX_G0802821Medical Research Council MC_U105579215Medical Research Council MC_UU_00005/4Wellcome Trust 200796/Z/16/Z
6 · The paper itself

Abstract

backgroundFew efficacious early treatments for post-traumatic stress disorder (PTSD) in children and adolescents exist. Previous trials have intervened within the first month post-trauma and focused on secondary prevention of later post-traumatic stress; however, considerable natural recovery may still occur up to 6-months post-trauma. No trials have addressed the early treatment of established PTSD (i.e. 2- to 6-months post-trauma).

methodsTwenty-nine youth (8-17 years) with PTSD (according to age-appropriate DSM-IV or ICD-10 diagnostic criteria) after a single-event trauma in the previous 2-6 months were randomly allocated to Cognitive Therapy for PTSD (CT-PTSD; n = 14) or waiting list (WL; n = 15) for 10 weeks.

resultsSignificantly more participants were free of PTSD after CT-PTSD (71%) than WL (27%) at posttreatment (intent-to-treat, 95% CI for difference .04-.71). CT-PTSD yielded greater improvement on child-report questionnaire measures of PTSD, depression and anxiety; clinician-rated functioning; and parent-reported outcomes. Recovery after CT-PTSD was maintained at 6- and 12-month posttreatment. Beneficial effects of CT-PTSD were mediated through changes in appraisals and safety-seeking behaviours, as predicted by cognitive models of PTSD. CT-PTSD was considered acceptable on the basis of low dropout and high treatment credibility and therapist alliance ratings.

conclusionsThis trial provides preliminary support for the efficacy and acceptability of CT-PTSD as an early treatment for PTSD in youth. Moreover, the trial did not support the extension of 'watchful waiting' into the 2- to 6-month post-trauma window, as significant improvements in the WL arm (particularly in terms of functioning and depression) were not observed. Replication in larger samples is needed, but attention to recruitment issues will be required.

Indexed as

Outcome Assessment, Health CareAdolescentChildCognitive Behavioral TherapyEarly Medical InterventionFemaleHumansMaleStress Disorders, Post-Traumaticcognitive therapyPost-traumatic stress disorder

Identifiers

PMID27976374
PMCPMC5362068

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.