Evidence map›Paper›PMID 27975300›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2017

Nephroprotective efficacy of ceftriaxone against cisplatin-induced subchronic renal fibrosis in rats.

Mohamed M Abdel-Daim, Yasser S El-Sayed, Mabrouk Abd Eldaim, Abdelazim Ibrahim

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 33 citations in OpenAlex.

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  4. Metabolic Profiling ofMetabolites · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Mohamed M Abdel-DaimPharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt. abdeldaim.m@vet.suez.edu.eg.
Yasser S El-SayedDepartment of Veterinary Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Damanhour University, Damanhour, 22511, Egypt.
Mabrouk Abd EldaimDepartment of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Sadat City University, Sadat City, 32897, Egypt.
Abdelazim IbrahimPathology Department, College of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt.
Damanhour University · EGKing Faisal University · SASuez Canal University · EGUniversity of Sadat City · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cisplatin, or cis-diamminedichloridoplatinum(II), (CDDP) is a broad-spectrum antineoplastic chemotherapeutic agent with a potent efficacy against several malignancies. Its main clinical antineoplastic therapy-limiting adverse effect is nephrotoxicity, where the developments of effective nephroprotectors are needed. Therefore, the present study aimed to investigate the nephroprotective and antifibrotic potential of ceftriaxone (CTX) against CDDP-induced toxicity. Male Wister rats were treated with saline or CTX (100 or 200 mg kg

Indexed as

CisplatinActinsAnimalsBiomarkersBromodeoxyuridineCeftriaxoneCell ProliferationCreatinineCytoprotectionDisease Models, AnimalFibrosisKidneyKidney DiseasesMaleProtective AgentsRats, WistarActa2 protein, ratActinsBiomarkersBromodeoxyuridineCeftriaxoneCisplatinCreatinineProtective AgentsTgfb1 protein, ratTransforming Growth Factor beta1UreaUric AcidAntifibroticBrdUCeftriaxoneCisplatinFibrosisImmunohistochemistryNephroprotectiveNephrotoxicityTGF-β1α-SMA

Identifiers

PMID27975300
OpenAlexW2564695125

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.