ArticlePlant molecular biology2017
Arabidopsis ANAC069 binds to C[A/G]CG[T/G] sequences to negatively regulate salt and osmotic stress tolerance.
Article in Plant molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 58 citations in OpenAlex.
- bHLH35 mediates specificity in plant responses to multiple stress conditions.Science advances · 2025Article
- Identification of Salt Tolerance-RelatedPlants (Basel, Switzerland) · 2025Article
- SlNAC12, a novel NAC-type transcription factor, confers salt stress tolerance in tomato.Plant cell reports · 2024Article
- Common Bean (International journal of molecular sciences · 2024Article
- Phosphorylation of birch BpNAC90 improves the activation of gene expression to confer drought tolerance.Horticulture research · 2024Article
- Article
- Genome-wide analysis of the Tritipyrum NAC gene family and the response of TtNAC477 in salt tolerance.BMC plant biology · 2024Article
- Molecular switches in plant stress adaptation.Molecular biology reports · 2023Review
- A Review of Potato Salt Tolerance.International journal of molecular sciences · 2023Review
- Review
- Biological Parts for Engineering Abiotic Stress Tolerance in Plants.Biodesign research · 2022Review
- Emerging Roles of Plant DNA-Binding With One Finger Transcription Factors in Various Hormone and Stress Signaling Pathways.Frontiers in plant science · 2022Article
- Article
- Alkaline stress reduces root waving by regulating PIN7 vacuolar transport.Frontiers in plant science · 2022Article
- Transcription Factors Interact with ABA through Gene Expression and Signaling Pathways to Mitigate Drought and Salinity Stress.Biomolecules · 2021Review
- Genome-wide identification, characterization, and expression analysis of the NAC transcription factor family in orchardgrass (Dactylis glomerata L.).BMC genomics · 2021Article
- Functional Characterization ofInternational journal of molecular sciences · 2021Article
- Potato NAC Transcription Factor StNAC053 Enhances Salt and Drought Tolerance in TransgenicInternational journal of molecular sciences · 2021Article
- The NAC-type transcription factor CaNAC46 regulates the salt and drought tolerance of transgenic Arabidopsis thaliana.BMC plant biology · 2021Article
- Genome-Wide Association Analysis Coupled With Transcriptome Analysis Reveals Candidate Genes Related to Salt Stress in Alfalfa (Frontiers in plant science · 2021Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key messageANAC069 binds to the DNA sequence of C[A/G]CG[T/G] to regulate the expression of genes, resulting in decreased ROS scavenging capability and proline biosynthesis, which contribute to increased sensitivity to salt and osmotic stress. NAM-ATAF1/2 and CUC2 (NAC) proteins are plant-specific transcription factors that play important roles in abiotic stress responses. In the present study, we characterized the physiological and regulatory roles of Arabidopsis thaliana ANAC069 in response to abiotic stresses. Arabidopsis plants overexpressing ANAC069 displayed increased sensitivity to abscisic acid, salt, and osmotic stress. Conversely, ANAC069 knockdown plants showed enhanced tolerance to salt and osmotic stress, but no change in ABA sensitivity. Further studies showed that ANAC069 inhibits the expression of SOD, POD, GST, and P5CS genes. Consequently, the transcript level of ANAC069 correlated negatively with the reactive oxygen species (ROS) scavenging ability and the proline level. The genes regulated by ANAC069 were further studied using a gene chip on a genome-wide scale, and 339 and 226 genes up- and downregulated by ANAC069 were identified. Analysis of the promoters of the genes affected by ANAC069 suggested that ANAC069 regulates the expression of genes mainly through interacting with the DNA sequence C[A/G]CG[T/G] in response to abiotic stresses. Collectively, our data suggest that ANAC069 could recognize C[A/G]CG[T/G] sequences to regulate the expression of genes that negatively regulates salt and osmotic stress tolerance by decreasing ROS scavenging capability and proline biosynthesis.
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