ArticleMetabolic brain disease2017
Vitamin D deficiency is associated with acute ischemic stroke, C-reactive protein, and short-term outcome.
Article in Metabolic brain disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 7 of them syntheses that pooled it.
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The trial behind it
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Who cites it
37 citing papers in PubMed, 7 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Systematic review and meta-analysis of stroke blood biomarker data highlights need for more translational research methods.Nature communications · 2026Pooled it
- Association between serum vitamin D levels and functional outcomes in ischemic stroke patients: A systematic review and meta-analysis.The Journal of international medical research · 2026Pooled it
- A systematic review and meta-analysis of the linkage between low vitamin D and the risk as well as the prognosis of stroke.Brain and behavior · 2024Pooled it
- Vitamin D supplementation and risk of stroke: A meta-analysis of randomized controlled trials.Frontiers in neurology · 2022Pooled it
- Vitamin D and Hyperkinetic Movement Disorders: A Systematic Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Pooled it
- Vitamin D and Stroke: Effects on Incidence, Severity, and Outcome and the Potential Benefits of Supplementation.Frontiers in neurology · 2020Pooled it
- Lower Vitamin D Status Is Associated with an Increased Risk of Ischemic Stroke: A Systematic Review and Meta-Analysis.Nutrients · 2018Pooled it
- Efficacy of low-fat milk and yogurt fortified with vitamin DJournal of health, population, and nutrition · 2022Trial
- Vitamin D Supplementation and Post-Stroke Rehabilitation: A Randomized, Double-Blind, Placebo-Controlled Trial.Nutrients · 2019Trial
- The interplay between diabetes and atherosclerosis: A review of pathophysiological mechanisms.ARYA atherosclerosis · 2025Review
- Influence of dual vitamin D therapy on the outcome in patients with moderate-to-severe acute anterior circulation cerebral infarction and vitamin D insufficiency.Frontiers in human neuroscience · 2025Article
- Novel Insights into the Molecular Mechanisms of Atherosclerosis.International journal of molecular sciences · 2023Review
- Effect of High-dose Vitamin D on IL-1β Blood Level in Patients with Moderate Stroke: A Randomized Clinical Trial.Anesthesiology and pain medicine · 2023Article
- Association Between Serum Vitamin D Levels and Physical Outcomes of Patients Who Underwent Rehabilitation Following Ischemic Stroke.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Vitamin D and Probability of Developmental Disorders among Perinatally HIV-Affected and Unaffected Ugandan Children.Nutrients · 2023Article
- Association of Long Non-Coding RNA Malat1 with Serum Levels of Interleukin-1 Beta and Vitamin D in Patients with Ischemic Stroke.Galen medical journal · 2023Article
- Vitamin D3 and Ischemic Stroke: A Narrative Review.Antioxidants (Basel, Switzerland) · 2022Review
- Hair cortisol in polycystic ovary syndrome.Scientific reports · 2022Article
- Surrogate biomarkers of outcome for wake-up ischemic stroke.BMC neurology · 2022Article
- Vitamin D and Parkinson's Disease.Nutrients · 2022Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate whether vitamin D deficiency (VDD) is associated with acute ischemic stroke, inflammatory markers, and short-term outcome. 168 acute ischemic stroke patients and 118 controls were included. The modified Rankin Scale (mRS) was applied up to 8 h of admission (baseline) and after three-months follow-up, and blood samples were obtained up to 24 h of admission to evaluate serum levels of 25-hydroxivitamin D [25(OH)D] and inflammatory markers. Vitamin D levels classified the individuals in sufficient (VDS ≥ 30.0 ng/mL), insufficient (VDI 20.0-29.9 ng/mL), and deficient (VDD < 20.0 ng/mL) status. Patients had lower levels of 25(OH)D, higher frequency of VDD (43.45% vs. 5.08%, OR: 16.64, 95% CI: 5.66-42.92, p < 0.001), and higher inflammatory markers than controls (p < 0.05). Patients with VDD showed increased high sensitivity C-reactive protein (hsCRP) levels than those with VDS status (p = 0.043); those with poor outcome presented with lower 25(OH)D levels than those with good outcome (p = 0.008); moreover, 25(OH)D levels were negatively correlated with mRS after three-months follow-up (r = -0.239, p = 0.005). The associations between VDD and higher hsCRP levels and between 25(OH)D levels and poor outcome at short-term in acute ischemic stroke patients suggest the important role of vitamin D in the inflammatory response and pathophysiology of this ischemic event.
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Registered trials
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