ArticleMolecular neurobiology2018
Minimally Toxic Dose of Lipopolysaccharide and α-Synuclein Oligomer Elicit Synergistic Dopaminergic Neurodegeneration: Role and Mechanism of Microglial NOX2 Activation.
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In one paragraph
Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- NADPH oxidases in Parkinson's disease: a systematic review.Molecular neurodegeneration · 2017Pooled it
- Roles of Microglia in Synaptogenesis, Synaptic Pruning, and Synaptic Plasticity in Physiological Conditions and Central Nervous System Disorders.Current neuropharmacology · 2026Review
- The Role of Interleukin-8 (IL-8) in Treatment-Resistant Depression: A Review of Mechanisms, Biomarker Potential, and Therapeutic Implications.International journal of molecular sciences · 2025Review
- Unraveling the Vicious Cycle: Oxidative Stress and Neurotoxicity in Neurodegenerative Diseases.FASEB bioAdvances · 2025Review
- Current methods for the microglia isolation: Overview and comparative analysis of approaches.Cell and tissue research · 2024Review
- Article
- NOX-induced oxidative stress is a primary trigger of major neurodegenerative disorders.Progress in neurobiology · 2023Review
- NADPH Oxidases: From Molecular Mechanisms to Current Inhibitors.Journal of medicinal chemistry · 2023Review
- Role of NADPH Oxidases in Blood-Brain Barrier Disruption and Ischemic Stroke.Antioxidants (Basel, Switzerland) · 2022Review
- Neuroinflammation and Parkinson's Disease-From Neurodegeneration to Therapeutic Opportunities.Cells · 2022Review
- NADPH oxidase 2 activity in Parkinson's disease.Neurobiology of disease · 2022Article
- Microglia and Neuroinflammation: Crucial Pathological Mechanisms in Traumatic Brain Injury-Induced Neurodegeneration.Frontiers in aging neuroscience · 2022Review
- Review
- Methamphetamine-induced dopaminergic neurotoxicity as a model of Parkinson's disease.Archives of pharmacal research · 2021Review
- NOX2 Activation in COVID-19: Possible Implications for Neurodegenerative Diseases.Medicina (Kaunas, Lithuania) · 2021Review
- Periphery and brain, innate and adaptive immunity in Parkinson's disease.Acta neuropathologica · 2021Review
- Norepinephrine depleting toxin DSP-4 and LPS alter gut microbiota and induce neurotoxicity in α-synuclein mutant mice.Scientific reports · 2020Article
- ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease.Antioxidants (Basel, Switzerland) · 2020Review
- Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's disease.Brain, behavior, and immunity · 2020Article
- Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 3 countries.
Wei ZhangDepartment of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China. ttyyzw@163.com.ORCID 0000-0002-5239-2312
Jun-Hua GaoDepartment of Neurology, Beijing Tiantian Hospital, Capital Medical University, Beijing, 100050, China.
Zhao-Fen YanDepartment of Neurology, Beijing Tiantian Hospital, Capital Medical University, Beijing, 100050, China.
Xi-Yan HuangDepartment of Neurology, Beijing Tiantian Hospital, Capital Medical University, Beijing, 100050, China.
Peng GuoDepartment of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
Li SunDepartment of Neurology, Beijing Tiantian Hospital, Capital Medical University, Beijing, 100050, China.
Zhuo LiuDepartment of Neurology, Beijing Tiantian Hospital, Capital Medical University, Beijing, 100050, China.
Yang HuDepartment of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
Li-Jun ZuoDepartment of Neurology, Beijing Tiantian Hospital, Capital Medical University, Beijing, 100050, China.
Shu-Yang YuDepartment of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
Chen-Jie CaoDepartment of Neurology, Beijing Tiantian Hospital, Capital Medical University, Beijing, 100050, China.
Xiao-Min WangKey Laboratory for Neurodegenerative Disorders of the Ministry of Education, Beijing, 100069, China.
Jau-Shyong HongNeuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, Durham, NC, 27709, USA.
Capital Medical University · CNMinistry of Education of the People's Republic of China · CNNational Institutes of Health · US
Funding
Roles Of Brain Neuroimmune System In NeurodegenerationZIAES090082 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HONG, JAU-SHYONG SHYONG · 2009 to 2018
$22.0MBasic-Clinical Research Cooperation Funding of Capital Medical University 2015-JL-PT-X04, 10JL49, 14JL15Capital Clinical Characteristic Application Research Z121107001012161Excellent Personnel Training Project of Beijing, China 20071D0300400076High Level Technical Personnel Training Project of Beijing Health System, China 2009-3-26Intramural NIH HHS ZIA ES090082Key Project of Beijing Natural Science Foundation, China kz201610025030, ,4161004, kz200910025001Key Project of National Natural Science Foundation of China 81030062National Key Technology Research and Development Program of the Ministry of Science and Technology of China 2013BAI09B03National Natural Science Foundation of China 30770745, 81071015, 81571229the Beijing Healthcare Research Project, China JING-15-2, JING-15-3the National Key Basic Research Program of China 2011CB504100the Natural Science Foundation of Beijing, China 7082032The project of Beijing Institute for Brain Disorders BIBD-PXM2013_014226_07_000084The Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges Under Beijing Municipality IDHT20140514Youth Research Fund, Beijing Tiantan Hospital, Capital Medical University, China 2014-YQN-YS-18, 2015-YQN-15, 2015-YQN-05, 2015-YQN-14, 2015-YQN-17
Abstract
The aim of this study is to investigate the role and mechanism of microglial NOX2 activation in minimally toxic dose of LPS and Syn-elicited synergistic dopaminergic neurodegeneration. NOX2
Indexed as
alpha-SynucleinAnimalsCell MembraneDopaminergic NeuronsEnzyme ActivationLipopolysaccharidesMice, Inbred C57BLMicrogliaNADPH Oxidase 2Nerve DegenerationNeuroprotectionNeurotoxinsProtein SubunitsRats, Sprague-DawleySignal Transductionalpha-SynucleinCybb protein, mouseLipopolysaccharidesNADPH Oxidase 2NeurotoxinsProtein SubunitsDopaminergic neurodegenerationEnvironmental factorsLipopolysaccharideMicroglial activationParkinson diseaseSynergisticα-Synuclein oligomer
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.