ArticleEuropean radiology2017
Re-exposure to low osmolar iodinated contrast media in patients with prior moderate-to-severe hypersensitivity reactions: A multicentre retrospective cohort study.
Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Hypersensitivity reactions to contrast media: Part 2. Prevention of recurrent hypersensitivity reactions in adults. Updated guidelines by the ESUR Contrast Media Safety Committee.European radiology · 2025Guideline
- Substituting with alternative iodinated contrast medium to prevent recurrent adverse drug reactions associated with its use: a meta-analysis.European radiology · 2025Pooled it
- Predictors of acute adverse reactions to non-ionic iodinated contrast media in CT imaging: a systematic review and meta-analysis.Frontiers in radiology · 2025Pooled it
- Risk factor analysis of iodinated contrast medium-related hypersensitivity reactions.Insights into imaging · 2025Review
- Hypersensitivity Reactions to Iodinated Contrast Media: A Narrative Review of Current Evidence and Clinical Challenges.Healthcare (Basel, Switzerland) · 2025Review
- Clinical characteristics and risk factors for escalation to anaphylaxis from non-severe drug hypersensitivity reaction.Clinical and translational allergy · 2025Article
- Are gadolinium-based contrast media safe alternatives to iodinated contrast agents for the safe performance of spinal injection procedures?Interventional pain medicine · 2025Article
- Hypersensitivity reactions to iodinated contrast media: potential mechanisms and clinical management.Frontiers in medicine · 2025Review
- Cross-reactivity in hypersensitivity reactions to contrast agents: new classification and guide for clinical practice.European radiology · 2024Article
- N-(2,3-dihydroxypropyl) carbamoyl side chain: a potentially significant factor for recurrent iodinated contrast medium-related adverse drug reactions.European radiology · 2024Article
- Indian College of Radiology and Imaging Consensus Guidelines on Interventions in Pancreatitis.The Indian journal of radiology & imaging · 2022Review
- Successful Adrenal Vein Sampling Using Dexamethasone Premedication in Patients With Iodine Contrast Media Allergy.Journal of the Endocrine Society · 2022Article
- Diagnosis and Prevention of Hypersensitivity Reactions to Iodinated Contrast Media.Allergy, asthma & immunology research · 2022Review
- Shelling the myth: allergies to Iodine containing substances and risk of reaction to Iodinated contrast media.Emergency radiology · 2022Article
- Adrenal Vein Sampling in a Patient With Primary Hyperaldosteronism and Severe Contrast Allergy.Journal of the Endocrine Society · 2021Article
- Acute Urticaria in Inpatients Undergoing Non-emergent Coronary Angiography With Corticosteroid Prophylaxis: A Retrospective Study.Frontiers in medicine · 2021Article
- Shared functional neural substrates in Parkinson's disease and drug-induced parkinsonism: association with dopaminergic depletion.Scientific reports · 2020Article
- Article
- Reduced iodinated contrast media dose and injection speed for CT: how much does this decrease the risk of a hypersensitivity reactions?Quantitative imaging in medicine and surgery · 2020Article
- Drug hypersensitivity reactions in Asia: regional issues and challenges.Asia Pacific allergy · 2020Review
Corrections and comments
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Authors and funding
13 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the outcomes of re-exposure to low-osmolar iodinated contrast medium (LOCM) in patients with a history of moderate-to-severe hypersensitivity reaction (HSR).
methodsWe retrospectively evaluated a cohort comprising all subjects satisfying the following conditions at 11 centres: (1) experienced a moderate-to-severe HSR to LOCM by December 2014, and (2) underwent contrast-enhanced computed tomography after the initial HSR between January 2014 and December 2014.
resultsA total of 150 patients with 328 instances of re-exposure were included; the recurrence rate of HSR was 19.5%. Patients with severe initial HSR exhibited a higher recurrence rate of severe HSR compared to patients with moderate initial HSR, despite more intensive premedication. In the multivariate analysis, the independent risk factors for recurrence of HSR were diabetes, chronic urticaria, drug allergy other than to iodinated contrast media (ICM) and severe initial HSR. The risk of recurrent HSR was 67.1% lower in cases where the implicated ICM was changed to another one (odds ratio: 0.329; P = 0.001). However, steroid premedication did not show protective effects against recurrent HSR.
conclusionIn high-risk patients who have previously experienced a moderate-to-severe initial HSR to LOCM, we should consider changing the implicated ICM to reduce recurrence risk. KEY POINTS: • In patients with moderate-to-severe HSR, steroid premedication only shows limited effectiveness. • Changing the implicated ICM can reduce the recurrence of HSR to ICM. • Diabetes, chronic urticaria and drug allergies increase the risk of ICM HSR.
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