Evidence map›Paper›PMID 27975103›Full record

ArticleThrombosis and haemostasis2017

Reasons for the persistent incidence of venous thromboembolism.

John A Heit, Aneel Ashrani, Daniel J Crusan, Robert D McBane, Tanya M Petterson, Kent R Bailey

Erratum issuedAbstract read
In one paragraph

Article in Thrombosis and haemostasis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. A real-time prognostic model for venous thromboembolic events among hospitalized adults.Research and practice in thrombosis and haemostasis · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. A review of venous thromboembolism in India.The Indian journal of medical research · 2023
    Review
  18. Laboratory Evaluation of Thrombophilia.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  19. Article
  20. [Clinical characteristics of patients with rheumatoid arthritis complicated with venous thrombosis of lower extremities].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

John A HeitJohn A. Heit, MD, Stabile 6-Hematology Research, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA, Tel.: +1 507 284 4634, Fax: +1 507 266 9302, E-mail: heit.john@mayo.edu.
Aneel Ashrani
Daniel J Crusan
Robert D McBane
Tanya M Petterson
Kent R Bailey

Funding

RISK FACTORS FOR VENOUS THROMBOEMBOLISM IN THE COMMUNITYR01HL066216 · NHLBI · MAYO CLINIC ROCHESTER · PI ASHRANI, ANEEL ARJUN, BAILEY, KENT R · 2001 to 2019
$10.4M
Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
NHLBI NIH HHS R01 HL066216NIA NIH HHS R01 AG034676
6 · The paper itself

Abstract

Reasons for trends in venous thromboembolism (VTE) incidence are uncertain. It was our objective to determine VTE incidence trends and risk factor prevalence, and estimate population-attributable risk (PAR) trends for each risk factor. In a population-based cohort study of all residents of Olmsted County, Minnesota from 1981-2010, annual incidence rates were calculated using incident VTE cases as the numerator and age- and sex-specific Olmsted County population estimates as the denominator. Poisson regression models were used to assess the relationship of crude incidence rates to year of diagnosis, age at diagnosis, and sex. Trends in annual prevalence of major VTE risk factors were estimated using linear regression. Poisson regression with time-dependent risk factors (person-years approach) was used to model the entire population of Olmsted County and derive the PAR. The age- and sex-adjusted annual VTE incidence, 1981-2010, did not change significantly. Over the time period, 1988-2010, the prevalence of obesity, surgery, active cancer and leg paresis increased. Patient age, hospitalisation, surgery, cancer, trauma, leg paresis and nursing home confinement jointly accounted for 79 % of incident VTE; obesity accounted for 33 % of incident idiopathic VTE. The increasing prevalence of obesity, cancer and surgery accounted in part for the persistent VTE incidence. The PAR of active cancer and surgery, 1981-2010, significantly increased. In conclusion, almost 80 % of incident VTE events are attributable to known major VTE risk factors and one-third of incident idiopathic VTE events are attributable to obesity. Increasing surgery PAR suggests that concurrent efforts to prevent VTE may have been insufficient.

Indexed as

AdolescentAdultAgedAged, 80 and overAge DistributionChildChild, PreschoolFemaleHumansIncidenceInfantInfant, NewbornLinear ModelsMaleMiddle AgedMinnesotaepidemiologyphlebitispulmonary embolismthrombophlebitisVenous thrombosis

Identifiers

PMID27975103
PMCPMC5597250

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.